Shen J - Search Results

1

Pharmacokinetics-Driven Optimization of 4(3 H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension.

Wang Z, Jiang X, Zhang X, Tian G, Yang R, Wu J, Zou X, Liu Z, Yang X, Wu C, Shi J, Li J, Suo J, Wang Y, Zhang R, Xu Z, Gong X, He Y, Zhu W, Aisa HA, Jiang H, Xu Y, Shen J. Wang Z, et al. Among authors: shen j. J Med Chem. 2019 May 23;62(10):4979-4990. doi: 10.1021/acs.jmedchem.9b00123. Epub 2019 May 8. J Med Chem. 2019. PMID: 31021628

2

Molecular modeling on kappa opioid receptor and its interaction with nonpeptide kappa opioid agonists.

Liu DX, Jiang HL, Shen JS, Zhu WL, Zhao L, Chen KX, Ji RY. Liu DX, et al. Among authors: shen js. Zhongguo Yao Li Xue Bao. 1999 Feb;20(2):131-6. Zhongguo Yao Li Xue Bao. 1999. PMID: 10437159 Free article.

3

Synthesis and phosphodiesterase 5 inhibitory activity of novel pyrido[1,2-e]purin-4(3H)-one derivatives.

Xia G, Li J, Peng A, Lai S, Zhang S, Shen J, Liu Z, Chen X, Ji R. Xia G, et al. Among authors: shen j. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2790-4. doi: 10.1016/j.bmcl.2005.03.102. Bioorg Med Chem Lett. 2005. PMID: 15878277

4

[Spectroscopic studies of aripiprazole].

Li JF, Liu AX, Xia GX, Nian YF, Shen JS. Li JF, et al. Guang Pu Xue Yu Guang Pu Fen Xi. 2007 May;27(5):863-7. Guang Pu Xue Yu Guang Pu Fen Xi. 2007. PMID: 17655090 Chinese.

5

[Signal transduction by protein tyrosine kinases and antitumor agents].

Mao YJ, Li HH, Li JF, Shen JS. Mao YJ, et al. Yao Xue Xue Bao. 2008 Apr;43(4):323-34. Yao Xue Xue Bao. 2008. PMID: 18664191 Review. Chinese.

6

2-Phenylquinazolin-4(3H)-one, a class of potent PDE5 inhibitors with high selectivity versus PDE6.

Duan H, Zheng J, Lai Q, Liu Z, Tian G, Wang Z, Li J, Shen J. Duan H, et al. Among authors: shen j. Bioorg Med Chem Lett. 2009 May 15;19(10):2777-9. doi: 10.1016/j.bmcl.2009.03.125. Epub 2009 Mar 28. Bioorg Med Chem Lett. 2009. PMID: 19375311

7

Multiple pharmacophore models combined with molecular docking: a reliable way for efficiently identifying novel PDE4 inhibitors with high structural diversity.

Chen Z, Tian G, Wang Z, Jiang H, Shen J, Zhu W. Chen Z, et al. Among authors: shen j. J Chem Inf Model. 2010 Apr 26;50(4):615-25. doi: 10.1021/ci9004173. J Chem Inf Model. 2010. PMID: 20353193

8

Sildenafil promotes adipogenesis through a PKG pathway.

Zhang X, Ji J, Yan G, Wu J, Sun X, Shen J, Jiang H, Wang H. Zhang X, et al. Among authors: shen j. Biochem Biophys Res Commun. 2010 Jun 11;396(4):1054-9. doi: 10.1016/j.bbrc.2010.05.064. Epub 2010 May 21. Biochem Biophys Res Commun. 2010. PMID: 20471953

9

4-Acetyl-2,3,4,5-tetra-hydro-1H-1,4-benzodiazepine.

Zhao QJ, Liu Z, Zheng J, Shen JS. Zhao QJ, et al. Among authors: shen js. Acta Crystallogr Sect E Struct Rep Online. 2008 May 3;64(Pt 6):o969. doi: 10.1107/S1600536808007927. Acta Crystallogr Sect E Struct Rep Online. 2008. PMID: 21202698 Free PMC article.

10

[Research progress of anti-influenza virus agents].

Zhang Q, Zhao QJ, Xiong RS, Li JF, Shen JS. Zhang Q, et al. Yao Xue Xue Bao. 2010 Mar;45(3):289-99. Yao Xue Xue Bao. 2010. PMID: 21351503 Review. Chinese.

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