Ascher DB - Search Results

1

Synthesis and Structure-Activity relationship of 1-(5-isoquinolinesulfonyl)piperazine analogues as inhibitors of Mycobacterium tuberculosis IMPDH.

Singh V, Pacitto A, Donini S, Ferraris DM, Boros S, Illyés E, Szokol B, Rizzi M, Blundell TL, Ascher DB, Pato J, Mizrahi V. Singh V, et al. Among authors: ascher db. Eur J Med Chem. 2019 Jul 15;174:309-329. doi: 10.1016/j.ejmech.2019.04.027. Epub 2019 Apr 15. Eur J Med Chem. 2019. PMID: 31055147 Free PMC article.

2

mCSM: predicting the effects of mutations in proteins using graph-based signatures.

Pires DE, Ascher DB, Blundell TL. Pires DE, et al. Among authors: ascher db. Bioinformatics. 2014 Feb 1;30(3):335-42. doi: 10.1093/bioinformatics/btt691. Epub 2013 Nov 26. Bioinformatics. 2014. PMID: 24281696 Free PMC article.

3

DUET: a server for predicting effects of mutations on protein stability using an integrated computational approach.

Pires DE, Ascher DB, Blundell TL. Pires DE, et al. Among authors: ascher db. Nucleic Acids Res. 2014 Jul;42(Web Server issue):W314-9. doi: 10.1093/nar/gku411. Epub 2014 May 14. Nucleic Acids Res. 2014. PMID: 24829462 Free PMC article.

4

Platinum: a database of experimentally measured effects of mutations on structurally defined protein-ligand complexes.

Pires DE, Blundell TL, Ascher DB. Pires DE, et al. Among authors: ascher db. Nucleic Acids Res. 2015 Jan;43(Database issue):D387-91. doi: 10.1093/nar/gku966. Epub 2014 Oct 16. Nucleic Acids Res. 2015. PMID: 25324307 Free PMC article.

5

Flexibility and small pockets at protein-protein interfaces: New insights into druggability.

Jubb H, Blundell TL, Ascher DB. Jubb H, et al. Among authors: ascher db. Prog Biophys Mol Biol. 2015 Oct;119(1):2-9. doi: 10.1016/j.pbiomolbio.2015.01.009. Epub 2015 Feb 7. Prog Biophys Mol Biol. 2015. PMID: 25662442 Free PMC article. Review.

6

Analysis of HGD Gene Mutations in Patients with Alkaptonuria from the United Kingdom: Identification of Novel Mutations.

Usher JL, Ascher DB, Pires DE, Milan AM, Blundell TL, Ranganath LR. Usher JL, et al. Among authors: ascher db. JIMD Rep. 2015;24:3-11. doi: 10.1007/8904_2014_380. Epub 2015 Feb 15. JIMD Rep. 2015. PMID: 25681086 Free PMC article.

7

pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures.

Pires DE, Blundell TL, Ascher DB. Pires DE, et al. Among authors: ascher db. J Med Chem. 2015 May 14;58(9):4066-72. doi: 10.1021/acs.jmedchem.5b00104. Epub 2015 Apr 22. J Med Chem. 2015. PMID: 25860834 Free PMC article.

8

Achieving high signal-to-noise in cell regulatory systems: Spatial organization of multiprotein transmembrane assemblies of FGFR and MET receptors.

Blaszczyk M, Harmer NJ, Chirgadze DY, Ascher DB, Blundell TL. Blaszczyk M, et al. Among authors: ascher db. Prog Biophys Mol Biol. 2015 Sep;118(3):103-11. doi: 10.1016/j.pbiomolbio.2015.04.007. Epub 2015 May 5. Prog Biophys Mol Biol. 2015. PMID: 25957048 Free PMC article. Review.

9

Lst4, the yeast Fnip1/2 orthologue, is a DENN-family protein.

Pacitto A, Ascher DB, Wong LH, Blaszczyk BK, Nookala RK, Zhang N, Dokudovskaya S, Levine TP, Blundell TL. Pacitto A, et al. Among authors: ascher db. Open Biol. 2015 Dec;5(12):150174. doi: 10.1098/rsob.150174. Open Biol. 2015. PMID: 26631379 Free PMC article.

10

In silico functional dissection of saturation mutagenesis: Interpreting the relationship between phenotypes and changes in protein stability, interactions and activity.

Pires DE, Chen J, Blundell TL, Ascher DB. Pires DE, et al. Among authors: ascher db. Sci Rep. 2016 Jan 22;6:19848. doi: 10.1038/srep19848. Sci Rep. 2016. PMID: 26797105 Free PMC article.

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