Lazo PA - Search Results

1

Olaparib and ionizing radiation trigger a cooperative DNA-damage repair response that is impaired by depletion of the VRK1 chromatin kinase.

Campillo-Marcos I, Lazo PA. Campillo-Marcos I, et al. Among authors: lazo pa. J Exp Clin Cancer Res. 2019 May 17;38(1):203. doi: 10.1186/s13046-019-1204-1. J Exp Clin Cancer Res. 2019. PMID: 31101118 Free PMC article.

2

The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein.

Lopez-Borges S, Lazo PA. Lopez-Borges S, et al. Among authors: lazo pa. Oncogene. 2000 Jul 27;19(32):3656-64. doi: 10.1038/sj.onc.1203709. Oncogene. 2000. PMID: 10951572

3

Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK.

Sevilla A, Santos CR, Vega FM, Lazo PA. Sevilla A, et al. Among authors: lazo pa. J Biol Chem. 2004 Jun 25;279(26):27458-65. doi: 10.1074/jbc.M401009200. Epub 2004 Apr 21. J Biol Chem. 2004. PMID: 15105425 Free article.

4

VRK1 signaling pathway in the context of the proliferation phenotype in head and neck squamous cell carcinoma.

Santos CR, Rodríguez-Pinilla M, Vega FM, Rodríguez-Peralto JL, Blanco S, Sevilla A, Valbuena A, Hernández T, van Wijnen AJ, Li F, de Alava E, Sánchez-Céspedes M, Lazo PA. Santos CR, et al. Among authors: lazo pa. Mol Cancer Res. 2006 Mar;4(3):177-85. doi: 10.1158/1541-7786.MCR-05-0212. Mol Cancer Res. 2006. PMID: 16547155

5

Identification of a dominant epitope in human vaccinia-related kinase 1 (VRK1) and detection of different intracellular subpopulations.

Valbuena A, López-Sánchez I, Vega FM, Sevilla A, Sanz-García M, Blanco S, Lazo PA. Valbuena A, et al. Among authors: lazo pa. Arch Biochem Biophys. 2007 Sep 1;465(1):219-26. doi: 10.1016/j.abb.2007.06.005. Epub 2007 Jun 14. Arch Biochem Biophys. 2007. PMID: 17617371

6

Alteration of the VRK1-p53 autoregulatory loop in human lung carcinomas.

Valbuena A, Suárez-Gauthier A, López-Rios F, López-Encuentra A, Blanco S, Fernández PL, Sánchez-Céspedes M, Lazo PA. Valbuena A, et al. Among authors: lazo pa. Lung Cancer. 2007 Dec;58(3):303-9. doi: 10.1016/j.lungcan.2007.06.023. Epub 2007 Aug 8. Lung Cancer. 2007. PMID: 17689819

7

Human VRK1 is an early response gene and its loss causes a block in cell cycle progression.

Valbuena A, López-Sánchez I, Lazo PA. Valbuena A, et al. Among authors: lazo pa. PLoS One. 2008 Feb 20;3(2):e1642. doi: 10.1371/journal.pone.0001642. PLoS One. 2008. PMID: 18286197 Free PMC article.

8

The C/H3 domain of p300 is required to protect VRK1 and VRK2 from their downregulation induced by p53.

Valbuena A, Blanco S, Vega FM, Lazo PA. Valbuena A, et al. Among authors: lazo pa. PLoS One. 2008 Jul 9;3(7):e2649. doi: 10.1371/journal.pone.0002649. PLoS One. 2008. PMID: 18612383 Free PMC article.

9

Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activities.

Sanz-García M, López-Sánchez I, Lazo PA. Sanz-García M, et al. Among authors: lazo pa. Mol Cell Proteomics. 2008 Nov;7(11):2199-214. doi: 10.1074/mcp.M700586-MCP200. Epub 2008 Jul 9. Mol Cell Proteomics. 2008. PMID: 18617507 Free PMC article.

10

Plk3 interacts with and specifically phosphorylates VRK1 in Ser342, a downstream target in a pathway that induces Golgi fragmentation.

López-Sánchez I, Sanz-García M, Lazo PA. López-Sánchez I, et al. Among authors: lazo pa. Mol Cell Biol. 2009 Mar;29(5):1189-201. doi: 10.1128/MCB.01341-08. Epub 2008 Dec 22. Mol Cell Biol. 2009. PMID: 19103756 Free PMC article.

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