Watterson DM - Search Results

1

Genetic knockout of myosin light chain kinase (MLCK210) prevents cerebral microhemorrhages and attenuates neuroinflammation in a mouse model of vascular cognitive impairment and dementia.

Braun DJ, Bachstetter AD, Sudduth TL, Wilcock DM, Watterson DM, Van Eldik LJ. Braun DJ, et al. Among authors: watterson dm. Geroscience. 2019 Oct;41(5):671-679. doi: 10.1007/s11357-019-00072-4. Epub 2019 May 19. Geroscience. 2019. PMID: 31104189 Free PMC article.

2

Protein kinase involved in lung injury susceptibility: evidence from enzyme isoform genetic knockout and in vivo inhibitor treatment.

Wainwright MS, Rossi J, Schavocky J, Crawford S, Steinhorn D, Velentza AV, Zasadzki M, Shirinsky V, Jia Y, Haiech J, Van Eldik LJ, Watterson DM. Wainwright MS, et al. Among authors: watterson dm. Proc Natl Acad Sci U S A. 2003 May 13;100(10):6233-8. doi: 10.1073/pnas.1031595100. Epub 2003 May 2. Proc Natl Acad Sci U S A. 2003. PMID: 12730364 Free PMC article.

3

Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo.

Clayburgh DR, Barrett TA, Tang Y, Meddings JB, Van Eldik LJ, Watterson DM, Clarke LL, Mrsny RJ, Turner JR. Clayburgh DR, et al. Among authors: watterson dm. J Clin Invest. 2005 Oct;115(10):2702-15. doi: 10.1172/JCI24970. Epub 2005 Sep 22. J Clin Invest. 2005. PMID: 16184195 Free PMC article.

4

Human amyloid beta-induced neuroinflammation is an early event in neurodegeneration.

Craft JM, Watterson DM, Van Eldik LJ. Craft JM, et al. Among authors: watterson dm. Glia. 2006 Apr 1;53(5):484-90. doi: 10.1002/glia.20306. Glia. 2006. PMID: 16369931

5

Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury.

Lloyd E, Somera-Molina K, Van Eldik LJ, Watterson DM, Wainwright MS. Lloyd E, et al. Among authors: watterson dm. J Neuroinflammation. 2008 Jun 30;5:28. doi: 10.1186/1742-2094-5-28. J Neuroinflammation. 2008. PMID: 18590543 Free PMC article.

6

Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ).

Bachstetter AD, Xing B, de Almeida L, Dimayuga ER, Watterson DM, Van Eldik LJ. Bachstetter AD, et al. Among authors: watterson dm. J Neuroinflammation. 2011 Jul 6;8:79. doi: 10.1186/1742-2094-8-79. J Neuroinflammation. 2011. PMID: 21733175 Free PMC article.

7

Early stage drug treatment that normalizes proinflammatory cytokine production attenuates synaptic dysfunction in a mouse model that exhibits age-dependent progression of Alzheimer's disease-related pathology.

Bachstetter AD, Norris CM, Sompol P, Wilcock DM, Goulding D, Neltner JH, St Clair D, Watterson DM, Van Eldik LJ. Bachstetter AD, et al. Among authors: watterson dm. J Neurosci. 2012 Jul 25;32(30):10201-10. doi: 10.1523/JNEUROSCI.1496-12.2012. J Neurosci. 2012. PMID: 22836255 Free PMC article.

8

Target engagement analysis and link to pharmacodynamic endpoint for a novel class of CNS-penetrant and efficacious p38α MAPK inhibitors.

Bachstetter AD, Watterson DM, Van Eldik LJ. Bachstetter AD, et al. Among authors: watterson dm. J Neuroimmune Pharmacol. 2014 Sep;9(4):454-60. doi: 10.1007/s11481-014-9543-3. Epub 2014 May 1. J Neuroimmune Pharmacol. 2014. PMID: 24789302 Free PMC article.

9

Generation and behavior characterization of CaMKIIβ knockout mice.

Bachstetter AD, Webster SJ, Tu T, Goulding DS, Haiech J, Watterson DM, Van Eldik LJ. Bachstetter AD, et al. Among authors: watterson dm. PLoS One. 2014 Aug 15;9(8):e105191. doi: 10.1371/journal.pone.0105191. eCollection 2014. PLoS One. 2014. PMID: 25127391 Free PMC article.

10

Attenuation of traumatic brain injury-induced cognitive impairment in mice by targeting increased cytokine levels with a small molecule experimental therapeutic.

Bachstetter AD, Webster SJ, Goulding DS, Morton JE, Watterson DM, Van Eldik LJ. Bachstetter AD, et al. Among authors: watterson dm. J Neuroinflammation. 2015 Apr 10;12:69. doi: 10.1186/s12974-015-0289-5. J Neuroinflammation. 2015. PMID: 25886256 Free PMC article.

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