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Inhibition of c-Jun-N-terminal kinase increases cardiac peroxisome proliferator-activated receptor alpha expression and fatty acid oxidation and prevents lipopolysaccharide-induced heart dysfunction.
Drosatos K, Drosatos-Tampakaki Z, Khan R, Homma S, Schulze PC, Zannis VI, Goldberg IJ. Drosatos K, et al. Among authors: schulze pc. J Biol Chem. 2011 Oct 21;286(42):36331-9. doi: 10.1074/jbc.M111.272146. Epub 2011 Aug 26. J Biol Chem. 2011. PMID: 21873422 Free PMC article.
Ventricular assist device implantation corrects myocardial lipotoxicity, reverses insulin resistance, and normalizes cardiac metabolism in patients with advanced heart failure.
Chokshi A, Drosatos K, Cheema FH, Ji R, Khawaja T, Yu S, Kato T, Khan R, Takayama H, Knöll R, Milting H, Chung CS, Jorde U, Naka Y, Mancini DM, Goldberg IJ, Schulze PC. Chokshi A, et al. Among authors: schulze pc. Circulation. 2012 Jun 12;125(23):2844-53. doi: 10.1161/CIRCULATIONAHA.111.060889. Epub 2012 May 14. Circulation. 2012. PMID: 22586279 Free PMC article.
Lipid Use and Misuse by the Heart.
Schulze PC, Drosatos K, Goldberg IJ. Schulze PC, et al. Circ Res. 2016 May 27;118(11):1736-51. doi: 10.1161/CIRCRESAHA.116.306842. Circ Res. 2016. PMID: 27230639 Free PMC article. Review.
Increased de novo ceramide synthesis and accumulation in failing myocardium.
Ji R, Akashi H, Drosatos K, Liao X, Jiang H, Kennel PJ, Brunjes DL, Castillero E, Zhang X, Deng LY, Homma S, George IJ, Takayama H, Naka Y, Goldberg IJ, Schulze PC. Ji R, et al. Among authors: schulze pc. JCI Insight. 2017 May 4;2(9):e82922. doi: 10.1172/jci.insight.82922. eCollection 2017 May 4. JCI Insight. 2017. PMID: 28469091 Free PMC article.
MicroRNA-195 Regulates Metabolism in Failing Myocardium Via Alterations in Sirtuin 3 Expression and Mitochondrial Protein Acetylation.
Zhang X, Ji R, Liao X, Castillero E, Kennel PJ, Brunjes DL, Franz M, Möbius-Winkler S, Drosatos K, George I, Chen EI, Colombo PC, Schulze PC. Zhang X, et al. Among authors: schulze pc. Circulation. 2018 May 8;137(19):2052-2067. doi: 10.1161/CIRCULATIONAHA.117.030486. Epub 2018 Jan 12. Circulation. 2018. PMID: 29330215 Free PMC article.
408 results