Gu LQ - Search Results

1

Bouchardatine analogue alleviates non-alcoholic hepatic fatty liver disease/non-alcoholic steatohepatitis in high-fat fed mice by inhibiting ATP synthase activity.

Rao Y, Lu YT, Li C, Song QQ, Xu YH, Xu Z, Hu YT, Yu H, Gao L, Gu LQ, Ye JM, Huang ZS. Rao Y, et al. Among authors: gu lq. Br J Pharmacol. 2019 Aug;176(16):2877-2893. doi: 10.1111/bph.14713. Epub 2019 Jul 4. Br J Pharmacol. 2019. PMID: 31113010 Free PMC article.

2

Discovery of natural alkaloid bouchardatine as a novel inhibitor of adipogenesis/lipogenesis in 3T3-L1 adipocytes.

Rao Y, Liu H, Gao L, Yu H, Tan JH, Ou TM, Huang SL, Gu LQ, Ye JM, Huang ZS. Rao Y, et al. Among authors: gu lq. Bioorg Med Chem. 2015 Aug 1;23(15):4719-4727. doi: 10.1016/j.bmc.2015.05.057. Epub 2015 Jun 5. Bioorg Med Chem. 2015. PMID: 26088335

3

Synthesis and Biological Evaluation of Novel Bouchardatine Derivatives as Potential Adipogenesis/Lipogenesis Inhibitors for Antiobesity Treatment.

Rao Y, Liu H, Gao L, Yu H, Ou TM, Tan JH, Huang SL, Wang HG, Li D, Gu LQ, Ye JM, Huang ZS. Rao Y, et al. Among authors: gu lq. J Med Chem. 2015 Dec 10;58(23):9395-413. doi: 10.1021/acs.jmedchem.5b01566. Epub 2015 Dec 1. J Med Chem. 2015. PMID: 26572282

4

Natural alkaloid bouchardatine ameliorates metabolic disorders in high-fat diet-fed mice by stimulating the sirtuin 1/liver kinase B-1/AMPK axis.

Rao Y, Yu H, Gao L, Lu YT, Xu Z, Liu H, Gu LQ, Ye JM, Huang ZS. Rao Y, et al. Among authors: gu lq. Br J Pharmacol. 2017 Aug;174(15):2457-2470. doi: 10.1111/bph.13855. Epub 2017 Jun 21. Br J Pharmacol. 2017. PMID: 28493443 Free PMC article.

5

Rutaecarpine analogues reduce lipid accumulation in adipocytes via inhibiting adipogenesis/lipogenesis with AMPK activation and UPR suppression.

Chen YC, Zeng XY, He Y, Liu H, Wang B, Zhou H, Chen JW, Liu PQ, Gu LQ, Ye JM, Huang ZS. Chen YC, et al. Among authors: gu lq. ACS Chem Biol. 2013 Oct 18;8(10):2301-11. doi: 10.1021/cb4003893. Epub 2013 Sep 6. ACS Chem Biol. 2013. PMID: 23962138

6

Inhibition of thioredoxin reductase by mansonone F analogues: Implications for anticancer activity.

Liu Z, Huang SL, Li MM, Huang ZS, Lee KS, Gu LQ. Liu Z, et al. Among authors: gu lq. Chem Biol Interact. 2009 Jan 15;177(1):48-57. doi: 10.1016/j.cbi.2008.09.002. Epub 2008 Sep 7. Chem Biol Interact. 2009. PMID: 18822278

7

Synthesis and biological evaluation of novel N,N'-bis-methylenedioxybenzyl-alkylenediamines as bivalent anti-Alzheimer disease ligands.

Luo W, Li YP, Tan JH, Gu LQ, Huang ZS. Luo W, et al. Among authors: gu lq. J Enzyme Inhib Med Chem. 2011 Oct;26(5):706-11. doi: 10.3109/14756366.2010.548329. Epub 2011 Jan 21. J Enzyme Inhib Med Chem. 2011. PMID: 21250822 Free article.

8

Synthesis and evaluation of 7,8-dehydrorutaecarpine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.

He Y, Yao PF, Chen SB, Huang ZH, Huang SL, Tan JH, Li D, Gu LQ, Huang ZS. He Y, et al. Among authors: gu lq. Eur J Med Chem. 2013 May;63:299-312. doi: 10.1016/j.ejmech.2013.02.014. Epub 2013 Feb 26. Eur J Med Chem. 2013. PMID: 23501115

9

Specific targeting of telomeric multimeric G-quadruplexes by a new triaryl-substituted imidazole.

Hu MH, Chen SB, Wang B, Ou TM, Gu LQ, Tan JH, Huang ZS. Hu MH, et al. Among authors: gu lq. Nucleic Acids Res. 2017 Feb 28;45(4):1606-1618. doi: 10.1093/nar/gkw1195. Nucleic Acids Res. 2017. PMID: 27923993 Free PMC article.

10

New Disubstituted Quindoline Derivatives Inhibiting Burkitt's Lymphoma Cell Proliferation by Impeding c-MYC Transcription.

Liu HY, Chen AC, Yin QK, Li Z, Huang SM, Du G, He JH, Zan LP, Wang SK, Xu YH, Tan JH, Ou TM, Li D, Gu LQ, Huang ZS. Liu HY, et al. Among authors: gu lq. J Med Chem. 2017 Jul 13;60(13):5438-5454. doi: 10.1021/acs.jmedchem.7b00099. Epub 2017 Jun 28. J Med Chem. 2017. PMID: 28603988

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