Nimmrich V - Search Results

1

Discovery of ABT-957: 1-Benzyl-5-oxopyrrolidine-2-carboxamides as selective calpain inhibitors with enhanced metabolic stability.

Jantos K, Kling A, Mack H, Hornberger W, Moeller A, Nimmrich V, Lao Y, Nijsen M. Jantos K, et al. Among authors: nimmrich v. Bioorg Med Chem Lett. 2019 Aug 1;29(15):1968-1973. doi: 10.1016/j.bmcl.2019.05.034. Epub 2019 May 18. Bioorg Med Chem Lett. 2019. PMID: 31133534

2

Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer's Disease: 2-(3-Phenyl-1H-pyrazol-1-yl)-nicotinamides.

Kling A, Jantos K, Mack H, Hornberger W, Drescher K, Nimmrich V, Relo A, Wicke K, Hutchins CW, Lao Y, Marsh K, Moeller A. Kling A, et al. Among authors: nimmrich v. J Med Chem. 2017 Aug 24;60(16):7123-7138. doi: 10.1021/acs.jmedchem.7b00731. Epub 2017 Aug 15. J Med Chem. 2017. PMID: 28759231

3

Anticonvulsant effects of structurally diverse GABA(B) positive allosteric modulators in the DBA/2J audiogenic seizure test: Comparison to baclofen and utility as a pharmacodynamic screening model.

Brown JW, Moeller A, Schmidt M, Turner SC, Nimmrich V, Ma J, Rueter LE, van der Kam E, Zhang M. Brown JW, et al. Among authors: nimmrich v. Neuropharmacology. 2016 Feb;101:358-69. doi: 10.1016/j.neuropharm.2015.10.009. Epub 2015 Oct 22. Neuropharmacology. 2016. PMID: 26471422

4

Inhibition of Calpain Prevents N-Methyl-D-aspartate-Induced Degeneration of the Nucleus Basalis and Associated Behavioral Dysfunction.

Nimmrich V, Szabo R, Nyakas C, Granic I, Reymann KG, Schröder UH, Gross G, Schoemaker H, Wicke K, Möller A, Luiten P. Nimmrich V, et al. J Pharmacol Exp Ther. 2008 Nov;327(2):343-52. doi: 10.1124/jpet.108.142679. Epub 2008 Aug 13. J Pharmacol Exp Ther. 2008. PMID: 18701765 Free article.

5

Neuronal Network Oscillations in Neurodegenerative Diseases.

Nimmrich V, Draguhn A, Axmacher N. Nimmrich V, et al. Neuromolecular Med. 2015 Sep;17(3):270-84. doi: 10.1007/s12017-015-8355-9. Epub 2015 Apr 29. Neuromolecular Med. 2015. PMID: 25920466 Review.

6

Establishment of a secondary screening assay for P/Q-type calcium channel blockers.

Hermann D, Mezler M, Swensen AM, Bruehl C, Obergrußerger A, Wicke K, Schoemaker H, Gross G, Draguhn A, Nimmrich V. Hermann D, et al. Among authors: nimmrich v. Comb Chem High Throughput Screen. 2013 Mar;16(3):233-43. doi: 10.2174/1386207311316030008. Comb Chem High Throughput Screen. 2013. PMID: 23228050

7

A monoclonal antibody against the receptor for advanced glycation end products attenuates inflammatory and neuropathic pain in the mouse.

Brederson JD, Strakhova M, Mills C, Barlow E, Meyer A, Nimmrich V, Leddy M, Simler G, Schmidt M, Jarvis M, Lacy S. Brederson JD, et al. Among authors: nimmrich v. Eur J Pain. 2016 Apr;20(4):607-14. doi: 10.1002/ejp.775. Epub 2015 Sep 22. Eur J Pain. 2016. PMID: 26392119

8

Globular amyloid beta-peptide oligomer - a homogenous and stable neuropathological protein in Alzheimer's disease.

Barghorn S, Nimmrich V, Striebinger A, Krantz C, Keller P, Janson B, Bahr M, Schmidt M, Bitner RS, Harlan J, Barlow E, Ebert U, Hillen H. Barghorn S, et al. Among authors: nimmrich v. J Neurochem. 2005 Nov;95(3):834-47. doi: 10.1111/j.1471-4159.2005.03407.x. Epub 2005 Aug 31. J Neurochem. 2005. PMID: 16135089 Free article.

9

Development and validation of a fluorescence-based HTS assay for the identification of P/Q-type calcium channel blockers.

Mezler M, Hermann D, Swensen AM, Draguhn A, Terstappen GC, Gross G, Schoemaker H, Freiberg G, Pratt S, Gopalakrishnan SM, Nimmrich V. Mezler M, et al. Among authors: nimmrich v. Comb Chem High Throughput Screen. 2012 Jun 1;15(5):372-85. doi: 10.2174/138620712800194503. Comb Chem High Throughput Screen. 2012. PMID: 22272661

10

Inhibition of calpain prevents NMDA-induced cell death and beta-amyloid-induced synaptic dysfunction in hippocampal slice cultures.

Nimmrich V, Reymann KG, Strassburger M, Schöder UH, Gross G, Hahn A, Schoemaker H, Wicke K, Möller A. Nimmrich V, et al. Br J Pharmacol. 2010 Apr;159(7):1523-31. doi: 10.1111/j.1476-5381.2010.00652.x. Epub 2010 Mar 3. Br J Pharmacol. 2010. PMID: 20233208 Free PMC article.

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