Espinosa AC - Search Results

1

E3 ubiquitin-protein ligase TRIM21-mediated lysine capture by UBE2E1 reveals substrate-targeting mode of a ubiquitin-conjugating E2.

Anandapadamanaban M, Kyriakidis NC, Csizmók V, Wallenhammar A, Espinosa AC, Ahlner A, Round AR, Trewhella J, Moche M, Wahren-Herlenius M, Sunnerhagen M. Anandapadamanaban M, et al. Among authors: espinosa ac. J Biol Chem. 2019 Jul 26;294(30):11404-11419. doi: 10.1074/jbc.RA119.008485. Epub 2019 Jun 3. J Biol Chem. 2019. PMID: 31160341 Free PMC article.

2

Structural, functional and immunologic characterization of folded subdomains in the Ro52 protein targeted in Sjögren's syndrome.

Ottosson L, Hennig J, Espinosa A, Brauner S, Wahren-Herlenius M, Sunnerhagen M. Ottosson L, et al. Mol Immunol. 2006 Feb;43(6):588-98. doi: 10.1016/j.molimm.2005.04.013. Mol Immunol. 2006. PMID: 15916807

3

Increased expression of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 in skin lesions of patients with lupus erythematosus.

Popovic K, Ek M, Espinosa A, Padyukov L, Harris HE, Wahren-Herlenius M, Nyberg F. Popovic K, et al. Arthritis Rheum. 2005 Nov;52(11):3639-45. doi: 10.1002/art.21398. Arthritis Rheum. 2005. PMID: 16255056 Free article.

4

The Sjogren's syndrome-associated autoantigen Ro52 is an E3 ligase that regulates proliferation and cell death.

Espinosa A, Zhou W, Ek M, Hedlund M, Brauner S, Popovic K, Horvath L, Wallerskog T, Oukka M, Nyberg F, Kuchroo VK, Wahren-Herlenius M. Espinosa A, et al. J Immunol. 2006 May 15;176(10):6277-85. doi: 10.4049/jimmunol.176.10.6277. J Immunol. 2006. PMID: 16670339

5

Interferon-alpha induces up-regulation and nuclear translocation of the Ro52 autoantigen as detected by a panel of novel Ro52-specific monoclonal antibodies.

Strandberg L, Ambrosi A, Espinosa A, Ottosson L, Eloranta ML, Zhou W, Elfving A, Greenfield E, Kuchroo VK, Wahren-Herlenius M. Strandberg L, et al. J Clin Immunol. 2008 May;28(3):220-31. doi: 10.1007/s10875-007-9157-0. J Clin Immunol. 2008. PMID: 18071879

6

The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide.

Espinosa A, Oke V, Elfving A, Nyberg F, Covacu R, Wahren-Herlenius M. Espinosa A, et al. Exp Cell Res. 2008 Dec 10;314(20):3605-13. doi: 10.1016/j.yexcr.2008.09.011. Epub 2008 Sep 25. Exp Cell Res. 2008. PMID: 18845142

7

High Ro52 expression in spontaneous and UV-induced cutaneous inflammation.

Oke V, Vassilaki I, Espinosa A, Strandberg L, Kuchroo VK, Nyberg F, Wahren-Herlenius M. Oke V, et al. J Invest Dermatol. 2009 Aug;129(8):2000-10. doi: 10.1038/jid.2008.453. Epub 2009 Feb 5. J Invest Dermatol. 2009. PMID: 19194477 Free article.

8

Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway.

Espinosa A, Dardalhon V, Brauner S, Ambrosi A, Higgs R, Quintana FJ, Sjöstrand M, Eloranta ML, Ní Gabhann J, Winqvist O, Sundelin B, Jefferies CA, Rozell B, Kuchroo VK, Wahren-Herlenius M. Espinosa A, et al. J Exp Med. 2009 Aug 3;206(8):1661-71. doi: 10.1084/jem.20090585. Epub 2009 Jul 27. J Exp Med. 2009. PMID: 19635858 Free PMC article.

9

Self protection from anti-viral responses--Ro52 promotes degradation of the transcription factor IRF7 downstream of the viral Toll-Like receptors.

Higgs R, Lazzari E, Wynne C, Ní Gabhann J, Espinosa A, Wahren-Herlenius M, Jefferies CA. Higgs R, et al. PLoS One. 2010 Jul 26;5(7):e11776. doi: 10.1371/journal.pone.0011776. PLoS One. 2010. PMID: 20668674 Free PMC article.

10

Anti-Ro52 autoantibodies from patients with Sjögren's syndrome inhibit the Ro52 E3 ligase activity by blocking the E3/E2 interface.

Espinosa A, Hennig J, Ambrosi A, Anandapadmanaban M, Abelius MS, Sheng Y, Nyberg F, Arrowsmith CH, Sunnerhagen M, Wahren-Herlenius M. Espinosa A, et al. J Biol Chem. 2011 Oct 21;286(42):36478-91. doi: 10.1074/jbc.M111.241786. Epub 2011 Aug 23. J Biol Chem. 2011. PMID: 21862588 Free PMC article.

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