Southworth DR - Search Results

1

Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase.

Rizo AN, Lin J, Gates SN, Tse E, Bart SM, Castellano LM, DiMaio F, Shorter J, Southworth DR. Rizo AN, et al. Among authors: southworth dr. Nat Commun. 2019 Jun 3;10(1):2393. doi: 10.1038/s41467-019-10150-y. Nat Commun. 2019. PMID: 31160557 Free PMC article.

2

The protein targeting factor Get3 functions as ATP-independent chaperone under oxidative stress conditions.

Voth W, Schick M, Gates S, Li S, Vilardi F, Gostimskaya I, Southworth DR, Schwappach B, Jakob U. Voth W, et al. Among authors: southworth dr. Mol Cell. 2014 Oct 2;56(1):116-27. doi: 10.1016/j.molcel.2014.08.017. Epub 2014 Sep 18. Mol Cell. 2014. PMID: 25242142 Free PMC article.

3

Mitochondrial peroxiredoxin functions as crucial chaperone reservoir in Leishmania infantum.

Teixeira F, Castro H, Cruz T, Tse E, Koldewey P, Southworth DR, Tomás AM, Jakob U. Teixeira F, et al. Among authors: southworth dr. Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):E616-24. doi: 10.1073/pnas.1419682112. Epub 2015 Feb 2. Proc Natl Acad Sci U S A. 2015. PMID: 25646478 Free PMC article.

4

A conserved histidine modulates HSPB5 structure to trigger chaperone activity in response to stress-related acidosis.

Rajagopal P, Tse E, Borst AJ, Delbecq SP, Shi L, Southworth DR, Klevit RE. Rajagopal P, et al. Among authors: southworth dr. Elife. 2015 May 11;4:e07304. doi: 10.7554/eLife.07304. Elife. 2015. PMID: 25962097 Free PMC article.

5

Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation.

Yokom AL, Gates SN, Jackrel ME, Mack KL, Su M, Shorter J, Southworth DR. Yokom AL, et al. Among authors: southworth dr. Nat Struct Mol Biol. 2016 Sep;23(9):830-7. doi: 10.1038/nsmb.3277. Epub 2016 Aug 1. Nat Struct Mol Biol. 2016. PMID: 27478928 Free PMC article.

6

Polyphosphate: A Conserved Modifier of Amyloidogenic Processes.

Cremers CM, Knoefler D, Gates S, Martin N, Dahl JU, Lempart J, Xie L, Chapman MR, Galvan V, Southworth DR, Jakob U. Cremers CM, et al. Among authors: southworth dr. Mol Cell. 2016 Sep 1;63(5):768-80. doi: 10.1016/j.molcel.2016.07.016. Epub 2016 Aug 25. Mol Cell. 2016. PMID: 27570072 Free PMC article.

7

BAG3 Is a Modular, Scaffolding Protein that physically Links Heat Shock Protein 70 (Hsp70) to the Small Heat Shock Proteins.

Rauch JN, Tse E, Freilich R, Mok SA, Makley LN, Southworth DR, Gestwicki JE. Rauch JN, et al. Among authors: southworth dr. J Mol Biol. 2017 Jan 6;429(1):128-141. doi: 10.1016/j.jmb.2016.11.013. Epub 2016 Nov 21. J Mol Biol. 2017. PMID: 27884606 Free PMC article.

8

Aggregation of Mod5 is affected by tRNA binding with implications for tRNA gene-mediated silencing.

Read DF, Waller TJ, Tse E, Southworth DR, Engelke DR, Smaldino PJ. Read DF, et al. Among authors: southworth dr. FEBS Lett. 2017 Jun;591(11):1601-1610. doi: 10.1002/1873-3468.12627. Epub 2017 May 22. FEBS Lett. 2017. PMID: 28303570 Free PMC article.

9

Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104.

Gates SN, Yokom AL, Lin J, Jackrel ME, Rizo AN, Kendsersky NM, Buell CE, Sweeny EA, Mack KL, Chuang E, Torrente MP, Su M, Shorter J, Southworth DR. Gates SN, et al. Among authors: southworth dr. Science. 2017 Jul 21;357(6348):273-279. doi: 10.1126/science.aan1052. Epub 2017 Jun 15. Science. 2017. PMID: 28619716 Free PMC article.

10

X-linked inhibitor of apoptosis protein (XIAP) is a client of heat shock protein 70 (Hsp70) and a biomarker of its inhibition.

Cesa LC, Shao H, Srinivasan SR, Tse E, Jain C, Zuiderweg ERP, Southworth DR, Mapp AK, Gestwicki JE. Cesa LC, et al. Among authors: southworth dr. J Biol Chem. 2018 Feb 16;293(7):2370-2380. doi: 10.1074/jbc.RA117.000634. Epub 2017 Dec 18. J Biol Chem. 2018. PMID: 29255093 Free PMC article.

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