Shah DK - Search Results

1

Correction to: A Translational Quantitative Systems Pharmacology Model for CD3 Bispecific Molecules: Application to Quantify T Cell-Mediated Tumor Cell Killing by P-Cadherin LP DART®.

Betts A, Haddish-Berhane N, Shah DK, van der Graaf PH, Barletta F, King L, Clark T, Kamperschroer C, Root A, Hooper A, Chen X. Betts A, et al. Among authors: shah dk. AAPS J. 2019 Jun 4;21(4):73. doi: 10.1208/s12248-019-0348-4. AAPS J. 2019. PMID: 31165304 Free PMC article.

2

Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human.

Shah DK, Betts AM. Shah DK, et al. J Pharmacokinet Pharmacodyn. 2012 Feb;39(1):67-86. doi: 10.1007/s10928-011-9232-2. Epub 2011 Dec 6. J Pharmacokinet Pharmacodyn. 2012. PMID: 22143261

3

Bench to bedside translation of antibody drug conjugates using a multiscale mechanistic PK/PD model: a case study with brentuximab-vedotin.

Shah DK, Haddish-Berhane N, Betts A. Shah DK, et al. J Pharmacokinet Pharmacodyn. 2012 Dec;39(6):643-59. doi: 10.1007/s10928-012-9276-y. Epub 2012 Nov 15. J Pharmacokinet Pharmacodyn. 2012. PMID: 23151991

4

Antibody biodistribution coefficients: inferring tissue concentrations of monoclonal antibodies based on the plasma concentrations in several preclinical species and human.

Shah DK, Betts AM. Shah DK, et al. MAbs. 2013 Mar-Apr;5(2):297-305. doi: 10.4161/mabs.23684. Epub 2013 Feb 13. MAbs. 2013. PMID: 23406896 Free PMC article.

5

Key bioanalytical measurements for antibody-drug conjugate development: PK/PD modelers' perspective.

Shah DK, Barletta F, Betts A, Hansel S. Shah DK, et al. Bioanalysis. 2013 May;5(9):989-92. doi: 10.4155/bio.13.78. Bioanalysis. 2013. PMID: 23641690 No abstract available.

6

On translation of antibody drug conjugates efficacy from mouse experimental tumors to the clinic: a PK/PD approach.

Haddish-Berhane N, Shah DK, Ma D, Leal M, Gerber HP, Sapra P, Barton HA, Betts AM. Haddish-Berhane N, et al. Among authors: shah dk. J Pharmacokinet Pharmacodyn. 2013 Oct;40(5):557-71. doi: 10.1007/s10928-013-9329-x. Epub 2013 Aug 10. J Pharmacokinet Pharmacodyn. 2013. PMID: 23933716

7

A priori prediction of tumor payload concentrations: preclinical case study with an auristatin-based anti-5T4 antibody-drug conjugate.

Shah DK, King LE, Han X, Wentland JA, Zhang Y, Lucas J, Haddish-Berhane N, Betts A, Leal M. Shah DK, et al. AAPS J. 2014 May;16(3):452-63. doi: 10.1208/s12248-014-9576-9. Epub 2014 Mar 1. AAPS J. 2014. PMID: 24578215 Free PMC article.

8

Antibody-drug conjugates: an emerging modality for the treatment of cancer.

Leal M, Sapra P, Hurvitz SA, Senter P, Wahl A, Schutten M, Shah DK, Haddish-Berhane N, Kabbarah O. Leal M, et al. Among authors: shah dk. Ann N Y Acad Sci. 2014 Aug;1321:41-54. doi: 10.1111/nyas.12499. Ann N Y Acad Sci. 2014. PMID: 25123209 Review.

9

Evolution of Antibody-Drug Conjugate Tumor Disposition Model to Predict Preclinical Tumor Pharmacokinetics of Trastuzumab-Emtansine (T-DM1).

Singh AP, Maass KF, Betts AM, Wittrup KD, Kulkarni C, King LE, Khot A, Shah DK. Singh AP, et al. Among authors: shah dk. AAPS J. 2016 Jul;18(4):861-75. doi: 10.1208/s12248-016-9904-3. Epub 2016 Mar 30. AAPS J. 2016. PMID: 27029797 Free PMC article.

10

Application of a PK-PD Modeling and Simulation-Based Strategy for Clinical Translation of Antibody-Drug Conjugates: a Case Study with Trastuzumab Emtansine (T-DM1).

Singh AP, Shah DK. Singh AP, et al. Among authors: shah dk. AAPS J. 2017 Jul;19(4):1054-1070. doi: 10.1208/s12248-017-0071-y. Epub 2017 Apr 3. AAPS J. 2017. PMID: 28374319 Free PMC article.

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