Rosenthal PJ - Search Results

1

Improvement of Asparagine Ethylenediamines as Anti-malarial Plasmodium-Selective Proteasome Inhibitors.

Zhan W, Visone J, Ouellette T, Harris JC, Wang R, Zhang H, Singh PK, Ginn J, Sukenick G, Wong TT, Okoro JI, Scales RM, Tumwebaze PK, Rosenthal PJ, Kafsack BFC, Cooper RA, Meinke PT, Kirkman LA, Lin G. Zhan W, et al. Among authors: rosenthal pj. J Med Chem. 2019 Jul 11;62(13):6137-6145. doi: 10.1021/acs.jmedchem.9b00363. Epub 2019 Jun 20. J Med Chem. 2019. PMID: 31177777 Free PMC article.

2

Stage-specific antimalarial activity of cysteine protease inhibitors.

Shenai BR, Semenov AV, Rosenthal PJ. Shenai BR, et al. Among authors: rosenthal pj. Biol Chem. 2002 May;383(5):843-7. doi: 10.1515/BC.2002.089. Biol Chem. 2002. PMID: 12108550

3

Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi.

Greenbaum DC, Mackey Z, Hansell E, Doyle P, Gut J, Caffrey CR, Lehrman J, Rosenthal PJ, McKerrow JH, Chibale K. Greenbaum DC, et al. Among authors: rosenthal pj. J Med Chem. 2004 Jun 3;47(12):3212-9. doi: 10.1021/jm030549j. J Med Chem. 2004. PMID: 15163200

4

Selection of cysteine protease inhibitor-resistant malaria parasites is accompanied by amplification of falcipain genes and alteration in inhibitor transport.

Singh A, Rosenthal PJ. Singh A, et al. Among authors: rosenthal pj. J Biol Chem. 2004 Aug 20;279(34):35236-41. doi: 10.1074/jbc.M404235200. Epub 2004 Jun 10. J Biol Chem. 2004. PMID: 15192087 Free article.

5

Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain.

Fujii N, Mallari JP, Hansell EJ, Mackey Z, Doyle P, Zhou YM, Gut J, Rosenthal PJ, McKerrow JH, Guy RK. Fujii N, et al. Among authors: rosenthal pj. Bioorg Med Chem Lett. 2005 Jan 3;15(1):121-3. doi: 10.1016/j.bmcl.2004.10.023. Bioorg Med Chem Lett. 2005. PMID: 15582423

6

Falcipain cysteine proteases require bipartite motifs for trafficking to the Plasmodium falciparum food vacuole.

Subramanian S, Sijwali PS, Rosenthal PJ. Subramanian S, et al. Among authors: rosenthal pj. J Biol Chem. 2007 Aug 24;282(34):24961-9. doi: 10.1074/jbc.M703316200. Epub 2007 Jun 12. J Biol Chem. 2007. PMID: 17565983 Free article.

7

Structures of falcipain-2 and falcipain-3 bound to small molecule inhibitors: implications for substrate specificity.

Kerr ID, Lee JH, Pandey KC, Harrison A, Sajid M, Rosenthal PJ, Brinen LS. Kerr ID, et al. Among authors: rosenthal pj. J Med Chem. 2009 Feb 12;52(3):852-7. doi: 10.1021/jm8013663. J Med Chem. 2009. PMID: 19128015 Free PMC article.

8

In vitro sensitivities of Plasmodium falciparum to different antimalarial drugs in Uganda.

Nsobya SL, Kiggundu M, Nanyunja S, Joloba M, Greenhouse B, Rosenthal PJ. Nsobya SL, et al. Among authors: rosenthal pj. Antimicrob Agents Chemother. 2010 Mar;54(3):1200-6. doi: 10.1128/AAC.01412-09. Epub 2010 Jan 11. Antimicrob Agents Chemother. 2010. PMID: 20065051 Free PMC article. Clinical Trial.

9

Falcipain inhibitors: optimization studies of the 2-pyrimidinecarbonitrile lead series.

Coterón JM, Catterick D, Castro J, Chaparro MJ, Díaz B, Fernández E, Ferrer S, Gamo FJ, Gordo M, Gut J, de las Heras L, Legac J, Marco M, Miguel J, Muñoz V, Porras E, de la Rosa JC, Ruiz JR, Sandoval E, Ventosa P, Rosenthal PJ, Fiandor JM. Coterón JM, et al. Among authors: rosenthal pj. J Med Chem. 2010 Aug 26;53(16):6129-52. doi: 10.1021/jm100556b. J Med Chem. 2010. PMID: 20672841

10

Incorporation of basic side chains into cryptolepine scaffold: structure-antimalarial activity relationships and mechanistic studies.

Lavrado J, Cabal GG, Prudêncio M, Mota MM, Gut J, Rosenthal PJ, Díaz C, Guedes RC, dos Santos DJ, Bichenkova E, Douglas KT, Moreira R, Paulo A. Lavrado J, et al. Among authors: rosenthal pj. J Med Chem. 2011 Feb 10;54(3):734-50. doi: 10.1021/jm101383f. Epub 2011 Jan 5. J Med Chem. 2011. PMID: 21207937

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