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Page 1
Improvement of Asparagine Ethylenediamines as Anti-malarial Plasmodium-Selective Proteasome Inhibitors.
Zhan W, Visone J, Ouellette T, Harris JC, Wang R, Zhang H, Singh PK, Ginn J, Sukenick G, Wong TT, Okoro JI, Scales RM, Tumwebaze PK, Rosenthal PJ, Kafsack BFC, Cooper RA, Meinke PT, Kirkman LA, Lin G. Zhan W, et al. Among authors: wong tt. J Med Chem. 2019 Jul 11;62(13):6137-6145. doi: 10.1021/acs.jmedchem.9b00363. Epub 2019 Jun 20. J Med Chem. 2019. PMID: 31177777 Free PMC article.
Development of a Highly Selective Plasmodium falciparum Proteasome Inhibitor with Anti-malaria Activity in Humanized Mice.
Zhan W, Zhang H, Ginn J, Leung A, Liu YJ, Michino M, Toita A, Okamoto R, Wong TT, Imaeda T, Hara R, Yukawa T, Chelebieva S, Tumwebaze PK, Lafuente-Monasterio MJ, Martinez-Martinez MS, Vendome J, Beuming T, Sato K, Aso K, Rosenthal PJ, Cooper RA, Meinke PT, Nathan CF, Kirkman LA, Lin G. Zhan W, et al. Among authors: wong tt. Angew Chem Int Ed Engl. 2021 Apr 19;60(17):9279-9283. doi: 10.1002/anie.202015845. Epub 2021 Mar 11. Angew Chem Int Ed Engl. 2021. PMID: 33433953 Free PMC article.
Macrocyclic Peptides that Selectively Inhibit the Mycobacterium tuberculosis Proteasome.
Zhang H, Hsu HC, Kahne SC, Hara R, Zhan W, Jiang X, Burns-Huang K, Ouellette T, Imaeda T, Okamoto R, Kawasaki M, Michino M, Wong TT, Toita A, Yukawa T, Moraca F, Vendome J, Saha P, Sato K, Aso K, Ginn J, Meinke PT, Foley M, Nathan CF, Darwin KH, Li H, Lin G. Zhang H, et al. Among authors: wong tt. J Med Chem. 2021 May 13;64(9):6262-6272. doi: 10.1021/acs.jmedchem.1c00296. Epub 2021 May 5. J Med Chem. 2021. PMID: 33949190 Free PMC article.
Design, Synthesis, and Optimization of Macrocyclic Peptides as Species-Selective Antimalaria Proteasome Inhibitors.
Zhang H, Ginn J, Zhan W, Liu YJ, Leung A, Toita A, Okamoto R, Wong TT, Imaeda T, Hara R, Yukawa T, Michino M, Vendome J, Beuming T, Sato K, Aso K, Meinke PT, Nathan CF, Kirkman LA, Lin G. Zhang H, et al. Among authors: wong tt. J Med Chem. 2022 Jul 14;65(13):9350-9375. doi: 10.1021/acs.jmedchem.2c00611. Epub 2022 Jun 21. J Med Chem. 2022. PMID: 35727231 Free PMC article.
Structure-Activity Relationship Studies of Antimalarial Plasmodium Proteasome Inhibitors─Part II.
Zhang H, Ginn J, Zhan W, Leung A, Liu YJ, Toita A, Okamoto R, Wong TT, Imaeda T, Hara R, Michino M, Yukawa T, Chelebieva S, Tumwebaze PK, Vendome J, Beuming T, Sato K, Aso K, Rosenthal PJ, Cooper RA, Liverton N, Foley M, Meinke PT, Nathan CF, Kirkman LA, Lin G. Zhang H, et al. Among authors: wong tt. J Med Chem. 2023 Jan 26;66(2):1484-1508. doi: 10.1021/acs.jmedchem.2c01651. Epub 2023 Jan 11. J Med Chem. 2023. PMID: 36630286 Free PMC article.
Discovery of novel serine palmitoyltransferase inhibitors as cancer therapeutic agents.
Kojima T, Asano Y, Kurasawa O, Hirata Y, Iwamura N, Wong TT, Saito B, Tanaka Y, Arai R, Yonemori K, Miyamoto Y, Sagiya Y, Yaguchi M, Shibata S, Mizutani A, Sano O, Adachi R, Satomi Y, Hirayama M, Aoyama K, Hiura Y, Kiba A, Kitamura S, Imamura S. Kojima T, et al. Among authors: wong tt. Bioorg Med Chem. 2018 May 15;26(9):2452-2465. doi: 10.1016/j.bmc.2018.04.008. Epub 2018 Apr 4. Bioorg Med Chem. 2018. PMID: 29669694
Clinical characteristics and outcome of central nervous system tumors harboring NTRK gene fusions.
Lamoureux AA, Fisher MJ, Lemelle L, Pfaff E, Amir-Yazdani P, Kramm C, De Wilde B, Kazanowska B, Hutter C, Pfister SM, Sturm D, Jones DTW, Orbach D, Pierron G, Raskin S, Drilon A, Diamond EL, Harada G, Zapotocky M, Zamecnik J, Krskova L, Ellezam B, Weil AG, Venne D, Barritault M, Leblond P, Coltin H, Hammad R, Tabori U, Hawkins C, Hansford JR, Meyran D, Erker C, McFadden K, Sato M, Gottardo NG, Dholaria H, Nørøxe DS, Goto H, Ziegler DS, Lin FY, Parsons DW, Lindsay H, Wong TT, Liu YL, Wu KS, Franson AT, Hwang E, Aguilar-Bonilla A, Cheng S, Cacciotti C, Massimino M, Schiavello E, Wood P, Hoffman LM, Cappellano A, Lassaletta A, Van Damme A, Llort A, Gerber NU, Spalato Ceruso M, Bendel AE, Skrypek M, Hamideh D, Mushtaq N, Walter A, Jabado N, Alsahlawi A, Farmer JP, Coleman C, Mueller S, Mazewski C, Aguilera D, Robison NJ, O'Halloran K, Abbou S, Berlanga P, Geoerger B, Øra I, Moertel CL, Razis ED, Vernadou A, Ducray F, Bronnimann C, Seizeur R, Clarke M, Resnick AC, Alves M, Jones C, Doz F, Laetsch TW, Perreault S. Lamoureux AA, et al. Among authors: wong tt. Clin Cancer Res. 2024 Dec 3. doi: 10.1158/1078-0432.CCR-24-0581. Online ahead of print. Clin Cancer Res. 2024. PMID: 39625867
Infants' Social Evaluation of Helpers and Hinderers: A Large-Scale, Multi-Lab, Coordinated Replication Study.
Lucca K, Yuen F, Wang Y, Alessandroni N, Allison O, Alvarez M, Axelsson EL, Baumer J, Baumgartner HA, Bertels J, Bhavsar M, Byers-Heinlein K, Capelier-Mourguy A, Chijiiwa H, Chin CS, Christner N, Cirelli LK, Corbit J, Daum MM, Doan T, Dresel M, Exner A, Fei W, Forbes SH, Franchin L, Frank MC, Geraci A, Giraud M, Gornik ME, Wiesmann CG, Grossmann T, Hadley IM, Havron N, Henderson AME, Matzner EH, Immel BA, Jankiewicz G, Jędryczka W, Kanakogi Y, Kominsky JF, Lew-Williams C, Liberman Z, Liu L, Liu Y, Loeffler MT, Martin A, Mayor J, Meng X, Misiak M, Moreau D, Nencheva ML, Oña LS, Otálora Y, Paulus M, Pepe B, Pickron CB, Powell LJ, Proft M, Quinn AA, Rakoczy H, Reschke PJ, Roth-Hanania R, Rothmaler K, Schlegelmilch K, Schlingloff-Nemecz L, Schmuckler MA, Schuwerk T, Seehagen S, Şen HH, Shainy MR, Silvestri V, Soderstrom M, Sommerville J, Song HJ, Sorokowski P, Stutz SE, Su Y, Taborda-Osorio H, Tan AWM, Tatone D, Taylor-Partridge T, Tsang CKA, Urbanek A, Uzefovsky F, Visser I, Wertz AE, Williams M, Wolsey K, Wong TT, Woodward AM, Wu Y, Zeng Z, Zimmer L, Hamlin JK. Lucca K, et al. Among authors: wong tt. Dev Sci. 2025 Jan;28(1):e13581. doi: 10.1111/desc.13581. Dev Sci. 2025. PMID: 39600132
574 results