Johnson ME - Search Results

1

Identification of Small Molecules Exhibiting Oxacillin Synergy through a Novel Assay for Inhibition of vraTSR Expression in Methicillin-Resistant Staphylococcus aureus.

Lee H, Boyle-Vavra S, Ren J, Jarusiewicz JA, Sharma LK, Hoagland DT, Yin S, Zhu T, Hevener KE, Ojeda I, Lee RE, Daum RS, Johnson ME. Lee H, et al. Among authors: johnson me. Antimicrob Agents Chemother. 2019 Aug 23;63(9):e02593-18. doi: 10.1128/AAC.02593-18. Print 2019 Sep. Antimicrob Agents Chemother. 2019. PMID: 31209003 Free PMC article.

2

Discovery of a novel and potent class of F. tularensis enoyl-reductase (FabI) inhibitors by molecular shape and electrostatic matching.

Hevener KE, Mehboob S, Su PC, Truong K, Boci T, Deng J, Ghassemi M, Cook JL, Johnson ME. Hevener KE, et al. Among authors: johnson me. J Med Chem. 2012 Jan 12;55(1):268-79. doi: 10.1021/jm201168g. Epub 2011 Dec 5. J Med Chem. 2012. PMID: 22098466 Free PMC article.

3

Reducing agents affect inhibitory activities of compounds: results from multiple drug targets.

Lee H, Torres J, Truong L, Chaudhuri R, Mittal A, Johnson ME. Lee H, et al. Among authors: johnson me. Anal Biochem. 2012 Apr 1;423(1):46-53. doi: 10.1016/j.ab.2012.01.006. Epub 2012 Jan 18. Anal Biochem. 2012. PMID: 22310499 Free PMC article.

4

Structural and enzymatic analyses reveal the binding mode of a novel series of Francisella tularensis enoyl reductase (FabI) inhibitors.

Mehboob S, Hevener KE, Truong K, Boci T, Santarsiero BD, Johnson ME. Mehboob S, et al. Among authors: johnson me. J Med Chem. 2012 Jun 28;55(12):5933-41. doi: 10.1021/jm300489v. Epub 2012 Jun 8. J Med Chem. 2012. PMID: 22642319 Free PMC article.

5

Identification of non-macrocyclic small molecule inhibitors against the NS3/4A serine protease of hepatitis C virus through in silico screening.

Chaudhuri R, Lee H, Truong L, Torres J, Patel K, Johnson ME. Chaudhuri R, et al. Among authors: johnson me. J Chem Inf Model. 2012 Aug 27;52(8):2245-56. doi: 10.1021/ci300177p. Epub 2012 Jul 20. J Chem Inf Model. 2012. PMID: 22697413

6

Expression, purification and characterization of enoyl-ACP reductase II, FabK, from Porphyromonas gingivalis.

Hevener KE, Mehboob S, Boci T, Truong K, Santarsiero BD, Johnson ME. Hevener KE, et al. Among authors: johnson me. Protein Expr Purif. 2012 Sep;85(1):100-8. doi: 10.1016/j.pep.2012.07.003. Epub 2012 Jul 20. Protein Expr Purif. 2012. PMID: 22820244 Free PMC article.

7

High-level expression, purification, and characterization of Staphylococcus aureus dihydroorotase (PyrC) as a cleavable His-SUMO fusion.

Truong L, Hevener KE, Rice AJ, Patel K, Johnson ME, Lee H. Truong L, et al. Among authors: johnson me. Protein Expr Purif. 2013 Mar;88(1):98-106. doi: 10.1016/j.pep.2012.11.018. Epub 2012 Dec 13. Protein Expr Purif. 2013. PMID: 23246866 Free PMC article.

8

Fragment-based drug discovery using a multidomain, parallel MD-MM/PBSA screening protocol.

Zhu T, Lee H, Lei H, Jones C, Patel K, Johnson ME, Hevener KE. Zhu T, et al. Among authors: johnson me. J Chem Inf Model. 2013 Mar 25;53(3):560-72. doi: 10.1021/ci300502h. Epub 2013 Mar 14. J Chem Inf Model. 2013. PMID: 23432621 Free PMC article.

9

Hit identification and optimization in virtual screening: practical recommendations based on a critical literature analysis.

Zhu T, Cao S, Su PC, Patel R, Shah D, Chokshi HB, Szukala R, Johnson ME, Hevener KE. Zhu T, et al. Among authors: johnson me. J Med Chem. 2013 Sep 12;56(17):6560-72. doi: 10.1021/jm301916b. Epub 2013 Jun 7. J Med Chem. 2013. PMID: 23688234 Free PMC article. Review.

10

A colorimetric assay optimization for high-throughput screening of dihydroorotase by detecting ureido groups.

Rice AJ, Truong L, Johnson ME, Lee H. Rice AJ, et al. Among authors: johnson me. Anal Biochem. 2013 Oct 1;441(1):87-94. doi: 10.1016/j.ab.2013.05.035. Epub 2013 Jun 13. Anal Biochem. 2013. PMID: 23769705

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