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Evaluation of Functional Selectivity of Haloperidol, Clozapine, and LASSBio-579, an Experimental Compound With Antipsychotic-Like Actions in Rodents, at G Protein and Arrestin Signaling Downstream of the Dopamine D2 Receptor.
Silva RR, Parreiras-E-Silva LT, Pompeu TET, Duarte DA, Fraga CAM, Barreiro EJ, Menegatti R, Costa-Neto CM, Noël F. Silva RR, et al. Among authors: pompeu tet. Front Pharmacol. 2019 Jun 4;10:628. doi: 10.3389/fphar.2019.00628. eCollection 2019. Front Pharmacol. 2019. PMID: 31214037 Free PMC article.
Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound.
Gomes TF, Pompeu TE, Rodrigues DA, Noël F, Menegatti R, Andrade CH, Sabino JR, Gil ES, Dalla Costa T, Betti AH, Antonio CB, Rates SM, Fraga CA, Barreiro EJ, de Oliveira V. Gomes TF, et al. Eur J Med Chem. 2013 Apr;62:214-21. doi: 10.1016/j.ejmech.2012.08.011. Epub 2012 Aug 20. Eur J Med Chem. 2013. PMID: 23353740
Partial agonism and fast dissociation of LASSBio-579 at dopamine D2 receptor.
Pompeu TE, Monteiro do Monte F, Bosier B, Fraga CA, Barreiro EJ, Menegatti R, Hermans E, Noël F. Pompeu TE, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2015 Oct 1;62:1-6. doi: 10.1016/j.pnpbp.2015.04.003. Epub 2015 Apr 17. Prog Neuropsychopharmacol Biol Psychiatry. 2015. PMID: 25891249 Free article.