Ramanujan S - Search Results

1

Preclinical and translational pharmacokinetics of a novel THIOMAB™ antibody-antibiotic conjugate against Staphylococcus aureus.

Deng R, Zhou C, Li D, Cai H, Sukumaran S, Carrasco-Triguero M, Saad O, Nazzal D, Lowe C, Ramanujan S, Kamath AV. Deng R, et al. Among authors: ramanujan s. MAbs. 2019 Aug/Sep;11(6):1162-1174. doi: 10.1080/19420862.2019.1627152. Epub 2019 Jun 20. MAbs. 2019. PMID: 31219754 Free PMC article.

2

Mechanism-Based Pharmacokinetic/Pharmacodynamic Model for THIOMAB™ Drug Conjugates.

Sukumaran S, Gadkar K, Zhang C, Bhakta S, Liu L, Xu K, Raab H, Yu SF, Mai E, Fourie-O'Donohue A, Kozak KR, Ramanujan S, Junutula JR, Lin K. Sukumaran S, et al. Among authors: ramanujan s. Pharm Res. 2015 Jun;32(6):1884-93. doi: 10.1007/s11095-014-1582-1. Epub 2014 Dec 2. Pharm Res. 2015. PMID: 25446772

3

Semi-mechanistic Multiple-Analyte Pharmacokinetic Model for an Antibody-Drug-Conjugate in Cynomolgus Monkeys.

Lu D, Jin JY, Girish S, Agarwal P, Li D, Prabhu S, Dere RC, Saad OM, Nazzal D, Koppada N, Ramanujan S, Ng CM. Lu D, et al. Among authors: ramanujan s. Pharm Res. 2015 Jun;32(6):1907-19. doi: 10.1007/s11095-014-1585-y. Epub 2014 Dec 3. Pharm Res. 2015. PMID: 25467958 Free PMC article.

4

Development and Translational Application of an Integrated, Mechanistic Model of Antibody-Drug Conjugate Pharmacokinetics.

Sukumaran S, Zhang C, Leipold DD, Saad OM, Xu K, Gadkar K, Samineni D, Wang B, Milojic-Blair M, Carrasco-Triguero M, Rubinfeld B, Fielder P, Lin K, Ramanujan S. Sukumaran S, et al. Among authors: ramanujan s. AAPS J. 2017 Jan;19(1):130-140. doi: 10.1208/s12248-016-9993-z. Epub 2016 Sep 27. AAPS J. 2017. PMID: 27679517

5

gPKPDSim: a SimBiology^®-based GUI application for PKPD modeling in drug development.

Hosseini I, Gajjala A, Bumbaca Yadav D, Sukumaran S, Ramanujan S, Paxson R, Gadkar K. Hosseini I, et al. Among authors: ramanujan s. J Pharmacokinet Pharmacodyn. 2018 Apr;45(2):259-275. doi: 10.1007/s10928-017-9562-9. Epub 2018 Jan 4. J Pharmacokinet Pharmacodyn. 2018. PMID: 29302838 Free PMC article.

6

Integrated systems modeling of severe asthma: Exploration of IL-33/ST2 antagonism.

Gadkar K, Feigelman J, Sukumaran S, Rodrigo MC, Staton T, Cai F, Bauer RN, Choy DF, Stokes CL, Scheerens H, Ramanujan S. Gadkar K, et al. Among authors: ramanujan s. CPT Pharmacometrics Syst Pharmacol. 2022 Sep;11(9):1268-1277. doi: 10.1002/psp4.12842. Epub 2022 Jul 20. CPT Pharmacometrics Syst Pharmacol. 2022. PMID: 35857704 Free PMC article.

7

A mechanistic PK/PD model to enable dose selection of the potent anti-tryptase antibody (MTPS9579A) in patients with moderate-to-severe asthma.

Rymut SM, Henderson LM, Poon V, Staton TL, Cai F, Sukumaran S, Rhee H, Owen R, Ramanujan S, Yoshida K. Rymut SM, et al. Among authors: ramanujan s. Clin Transl Sci. 2023 Apr;16(4):694-703. doi: 10.1111/cts.13483. Epub 2023 Feb 8. Clin Transl Sci. 2023. PMID: 36755366 Free PMC article.

8

A Minimal PBPK/PD Model with Expansion-Enhanced Target-Mediated Drug Disposition to Support a First-in-Human Clinical Study Design for a FLT3L-Fc Molecule.

Hosseini I, Fleisher B, Getz J, Decalf J, Kwong M, Ovacik M, Bainbridge TW, Moussion C, Rao GK, Gadkar K, Kamath AV, Ramanujan S. Hosseini I, et al. Among authors: ramanujan s. Pharmaceutics. 2024 May 15;16(5):660. doi: 10.3390/pharmaceutics16050660. Pharmaceutics. 2024. PMID: 38794321 Free PMC article.

9

Prospective Design of Anti-Transferrin Receptor Bispecific Antibodies for Optimal Delivery into the Human Brain.

Kanodia JS, Gadkar K, Bumbaca D, Zhang Y, Tong RK, Luk W, Hoyte K, Lu Y, Wildsmith KR, Couch JA, Watts RJ, Dennis MS, Ernst JA, Scearce-Levie K, Atwal JK, Ramanujan S, Joseph S. Kanodia JS, et al. Among authors: ramanujan s. CPT Pharmacometrics Syst Pharmacol. 2016 May;5(5):283-91. doi: 10.1002/psp4.12081. Epub 2016 May 17. CPT Pharmacometrics Syst Pharmacol. 2016. PMID: 27299941 Free PMC article.

10

A Preclinical Population Pharmacokinetic Model for Anti-CD20/CD3 T-Cell-Dependent Bispecific Antibodies.

Ferl GZ, Reyes A, Sun LL, Cheu M, Oldendorp A, Ramanujan S, Stefanich EG. Ferl GZ, et al. Among authors: ramanujan s. Clin Transl Sci. 2018 May;11(3):296-304. doi: 10.1111/cts.12535. Epub 2018 Jan 19. Clin Transl Sci. 2018. PMID: 29351372 Free PMC article.

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