Brown N - Search Results

1

Discovery and development of DNA polymerase IIIC inhibitors to treat Gram-positive infections.

Xu WC, Silverman MH, Yu XY, Wright G, Brown N. Xu WC, et al. Among authors: brown n. Bioorg Med Chem. 2019 Aug 1;27(15):3209-3217. doi: 10.1016/j.bmc.2019.06.017. Epub 2019 Jun 11. Bioorg Med Chem. 2019. PMID: 31221610 Free article. Review.

2

Synthesis of substituted 6-anilinouracils and their inhibition of DNA polymerase IIIC and Gram-positive bacterial growth.

Zhi C, Long ZY, Gambino J, Xu WC, Brown NC, Barnes M, Butler M, LaMarr W, Wright GE. Zhi C, et al. J Med Chem. 2003 Jun 19;46(13):2731-9. doi: 10.1021/jm020591z. J Med Chem. 2003. PMID: 12801236

3

Active site directed inhibitors of replication-specific bacterial DNA polymerases.

Wright GE, Brown NC, Xu WC, Long ZY, Zhi C, Gambino JJ, Barnes MH, Butler MM. Wright GE, et al. Bioorg Med Chem Lett. 2005 Feb 1;15(3):729-32. doi: 10.1016/j.bmcl.2004.11.016. Bioorg Med Chem Lett. 2005. PMID: 15664846

4

Hybrid antibacterials. DNA polymerase-topoisomerase inhibitors.

Zhi C, Long ZY, Manikowski A, Comstock J, Xu WC, Brown NC, Tarantino PM Jr, Holm KA, Dix EJ, Wright GE, Barnes MH, Butler MM, Foster KA, LaMarr WA, Bachand B, Bethell R, Cadilhac C, Charron S, Lamothe S, Motorina I, Storer R. Zhi C, et al. J Med Chem. 2006 Feb 23;49(4):1455-65. doi: 10.1021/jm0510023. J Med Chem. 2006. PMID: 16480282 Free PMC article.

5

7-Alkyl-N(2)-substituted-3-deazaguanines. Synthesis, DNA polymerase III inhibition and antibacterial activity.

Xu WC, Wright GE, Brown NC, Long ZY, Zhi CX, Dvoskin S, Gambino JJ, Barnes MH, Butler MM. Xu WC, et al. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4197-202. doi: 10.1016/j.bmcl.2011.05.093. Epub 2011 May 30. Bioorg Med Chem Lett. 2011. PMID: 21684746 Free PMC article.

6

Synthesis and antibacterial activity of 3-substituted-6-(3-ethyl-4-methylanilino)uracils.

Zhi C, Long ZY, Manikowski A, Brown NC, Tarantino PM Jr, Holm K, Dix EJ, Wright GE, Foster KA, Butler MM, LaMarr WA, Skow DJ, Motorina I, Lamothe S, Storer R. Zhi C, et al. J Med Chem. 2005 Nov 3;48(22):7063-74. doi: 10.1021/jm050517r. J Med Chem. 2005. PMID: 16250666

7

A novel agent effective against Clostridium difficile infection.

Dvoskin S, Xu WC, Brown NC, Yanachkov IB, Yanachkova M, Wright GE. Dvoskin S, et al. Antimicrob Agents Chemother. 2012 Mar;56(3):1624-6. doi: 10.1128/AAC.06097-11. Epub 2011 Dec 27. Antimicrob Agents Chemother. 2012. PMID: 22203600 Free PMC article.

8

Antimicrobials targeted to the replication-specific DNA polymerases of gram-positive bacteria: target potential of dnaE.

Barnes MH, Butler MM, Wright GE, Brown NC. Barnes MH, et al. Infect Disord Drug Targets. 2012 Oct;12(5):327-31. doi: 10.2174/187152612804142279. Infect Disord Drug Targets. 2012. PMID: 23017159

9

Interaction of GTP derivatives with cellular and oncogenic ras-p21 proteins.

Noonan T, Brown N, Dudycz L, Wright G. Noonan T, et al. Among authors: brown n. J Med Chem. 1991 Apr;34(4):1302-7. doi: 10.1021/jm00108a010. J Med Chem. 1991. PMID: 2016705

10

Development of novel inhibitor probes of DNA polymerase III based on dGTP analogs of the HPUra type: base, nucleoside and nucleotide derivatives of N2-(3,4-dichlorobenzyl)guanine.

Butler MM, Dudycz LW, Khan NN, Wright GE, Brown NC. Butler MM, et al. Among authors: brown nc. Nucleic Acids Res. 1990 Dec 25;18(24):7381-7. doi: 10.1093/nar/18.24.7381. Nucleic Acids Res. 1990. PMID: 2259629 Free PMC article.

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