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Page 1
A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1.
De Luca A, Parker LJ, Ang WH, Rodolfo C, Gabbarini V, Hancock NC, Palone F, Mazzetti AP, Menin L, Morton CJ, Parker MW, Lo Bello M, Dyson PJ. De Luca A, et al. Among authors: parker mw, parker lj. Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):13943-13951. doi: 10.1073/pnas.1903297116. Epub 2019 Jun 20. Proc Natl Acad Sci U S A. 2019. PMID: 31221747 Free PMC article.
Studies of glutathione transferase P1-1 bound to a platinum(IV)-based anticancer compound reveal the molecular basis of its activation.
Parker LJ, Italiano LC, Morton CJ, Hancock NC, Ascher DB, Aitken JB, Harris HH, Campomanes P, Rothlisberger U, De Luca A, Lo Bello M, Ang WH, Dyson PJ, Parker MW. Parker LJ, et al. Among authors: parker mw. Chemistry. 2011 Jul 4;17(28):7806-16. doi: 10.1002/chem.201100586. Epub 2011 Jun 16. Chemistry. 2011. PMID: 21681839
Glutathione transferase P1-1 as an arsenic drug-sequestering enzyme.
Parker LJ, Bocedi A, Ascher DB, Aitken JB, Harris HH, Lo Bello M, Ricci G, Morton CJ, Parker MW. Parker LJ, et al. Among authors: parker mw. Protein Sci. 2017 Feb;26(2):317-326. doi: 10.1002/pro.3084. Epub 2016 Dec 14. Protein Sci. 2017. PMID: 27863446 Free PMC article.
Rational design of an organometallic glutathione transferase inhibitor.
Ang WH, Parker LJ, De Luca A, Juillerat-Jeanneret L, Morton CJ, Lo Bello M, Parker MW, Dyson PJ. Ang WH, et al. Among authors: parker mw, parker lj. Angew Chem Int Ed Engl. 2009;48(21):3854-7. doi: 10.1002/anie.200900185. Angew Chem Int Ed Engl. 2009. PMID: 19396894 Free article.
Calorimetric and structural studies of the nitric oxide carrier S-nitrosoglutathione bound to human glutathione transferase P1-1.
Téllez-Sanz R, Cesareo E, Nuccetelli M, Aguilera AM, Barón C, Parker LJ, Adams JJ, Morton CJ, Lo Bello M, Parker MW, García-Fuentes L. Téllez-Sanz R, et al. Among authors: parker mw, parker lj. Protein Sci. 2006 May;15(5):1093-105. doi: 10.1110/ps.052055206. Epub 2006 Apr 5. Protein Sci. 2006. PMID: 16597834 Free PMC article.
The anti-cancer drug chlorambucil as a substrate for the human polymorphic enzyme glutathione transferase P1-1: kinetic properties and crystallographic characterisation of allelic variants.
Parker LJ, Ciccone S, Italiano LC, Primavera A, Oakley AJ, Morton CJ, Hancock NC, Bello ML, Parker MW. Parker LJ, et al. Among authors: parker mw. J Mol Biol. 2008 Jun 27;380(1):131-44. doi: 10.1016/j.jmb.2008.04.066. Epub 2008 May 4. J Mol Biol. 2008. PMID: 18511072 Free article.
Influence of the H-site residue 108 on human glutathione transferase P1-1 ligand binding: structure-thermodynamic relationships and thermal stability.
Quesada-Soriano I, Parker LJ, Primavera A, Casas-Solvas JM, Vargas-Berenguel A, Barón C, Morton CJ, Mazzetti AP, Lo Bello M, Parker MW, García-Fuentes L. Quesada-Soriano I, et al. Among authors: parker mw, parker lj. Protein Sci. 2009 Dec;18(12):2454-70. doi: 10.1002/pro.253. Protein Sci. 2009. PMID: 19780048 Free PMC article.
Diuretic drug binding to human glutathione transferase P1-1: potential role of Cys-101 revealed in the double mutant C47S/Y108V.
Quesada-Soriano I, Parker LJ, Primavera A, Wielens J, Holien JK, Casas-Solvas JM, Vargas-Berenguel A, Aguilera AM, Nuccetelli M, Mazzetti AP, Lo Bello M, Parker MW, García-Fuentes L. Quesada-Soriano I, et al. Among authors: parker mw, parker lj. J Mol Recognit. 2011 Mar-Apr;24(2):220-34. doi: 10.1002/jmr.1040. J Mol Recognit. 2011. PMID: 20540076
Structural approaches to probing metal interaction with proteins.
Parker LJ, Ascher DB, Gao C, Miles LA, Harris HH, Parker MW. Parker LJ, et al. Among authors: parker mw. J Inorg Biochem. 2012 Oct;115:138-47. doi: 10.1016/j.jinorgbio.2012.02.015. Epub 2012 Mar 3. J Inorg Biochem. 2012. PMID: 22437159 Review.
64 results