Schüle R - Search Results

1

Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1).

Xiong Y, Greschik H, Johansson C, Seifert L, Bacher J, Park KS, Babault N, Martini M, Fagan V, Li F, Chau I, Christott T, Dilworth D, Barsyte-Lovejoy D, Vedadi M, Arrowsmith CH, Brennan P, Fedorov O, Jung M, Farnie G, Liu J, Oppermann U, Schüle R, Jin J. Xiong Y, et al. Among authors: schule r. J Med Chem. 2019 Oct 24;62(20):8996-9007. doi: 10.1021/acs.jmedchem.9b00522. Epub 2019 Jul 24. J Med Chem. 2019. PMID: 31260300

2

Germ cell nuclear factor: an orphan receptor with unexpected properties.

Greschik H, Schüle R. Greschik H, et al. Among authors: schule r. J Mol Med (Berl). 1998 Nov-Dec;76(12):800-10. doi: 10.1007/s001090050284. J Mol Med (Berl). 1998. PMID: 9846950 Review.

3

Target-based approach to inhibitors of histone arginine methyltransferases.

Spannhoff A, Heinke R, Bauer I, Trojer P, Metzger E, Gust R, Schüle R, Brosch G, Sippl W, Jung M. Spannhoff A, et al. Among authors: schule r. J Med Chem. 2007 May 17;50(10):2319-25. doi: 10.1021/jm061250e. Epub 2007 Apr 14. J Med Chem. 2007. PMID: 17432842

4

A novel arginine methyltransferase inhibitor with cellular activity.

Spannhoff A, Machmur R, Heinke R, Trojer P, Bauer I, Brosch G, Schüle R, Hanefeld W, Sippl W, Jung M. Spannhoff A, et al. Among authors: schule r. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4150-3. doi: 10.1016/j.bmcl.2007.05.088. Epub 2007 Jun 3. Bioorg Med Chem Lett. 2007. PMID: 17570663

5

Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1.

Bissinger EM, Heinke R, Spannhoff A, Eberlin A, Metzger E, Cura V, Hassenboehler P, Cavarelli J, Schüle R, Bedford MT, Sippl W, Jung M. Bissinger EM, et al. Among authors: schule r. Bioorg Med Chem. 2011 Jun 15;19(12):3717-31. doi: 10.1016/j.bmc.2011.02.032. Epub 2011 Feb 27. Bioorg Med Chem. 2011. PMID: 21440447

6

Screening assays for epigenetic targets using native histones as substrates.

Hauser AT, Bissinger EM, Metzger E, Repenning A, Bauer UM, Mai A, Schüle R, Jung M. Hauser AT, et al. Among authors: schule r. J Biomol Screen. 2012 Jan;17(1):18-26. doi: 10.1177/1087057111423968. Epub 2011 Sep 30. J Biomol Screen. 2012. PMID: 21965113

7

Lestaurtinib inhibits histone phosphorylation and androgen-dependent gene expression in prostate cancer cells.

Köhler J, Erlenkamp G, Eberlin A, Rumpf T, Slynko I, Metzger E, Schüle R, Sippl W, Jung M. Köhler J, et al. Among authors: schule r. PLoS One. 2012;7(4):e34973. doi: 10.1371/journal.pone.0034973. Epub 2012 Apr 20. PLoS One. 2012. PMID: 22532837 Free PMC article.

8

Nonpeptidic propargylamines as inhibitors of lysine specific demethylase 1 (LSD1) with cellular activity.

Schmitt ML, Hauser AT, Carlino L, Pippel M, Schulz-Fincke J, Metzger E, Willmann D, Yiu T, Barton M, Schüle R, Sippl W, Jung M. Schmitt ML, et al. Among authors: schule r. J Med Chem. 2013 Sep 26;56(18):7334-42. doi: 10.1021/jm400792m. Epub 2013 Sep 5. J Med Chem. 2013. PMID: 24007511 Free PMC article.

9

Heterogeneous Antibody-Based Activity Assay for Lysine Specific Demethylase 1 (LSD1) on a Histone Peptide Substrate.

Schmitt ML, Ladwein KI, Carlino L, Schulz-Fincke J, Willmann D, Metzger E, Schilcher P, Imhof A, Schüle R, Sippl W, Jung M. Schmitt ML, et al. Among authors: schule r. J Biomol Screen. 2014 Jul;19(6):973-8. doi: 10.1177/1087057114529156. Epub 2014 Mar 31. J Biomol Screen. 2014. PMID: 24687155

10

The histone code reader SPIN1 controls RET signaling in liposarcoma.

Franz H, Greschik H, Willmann D, Ozretić L, Jilg CA, Wardelmann E, Jung M, Buettner R, Schüle R. Franz H, et al. Among authors: schule r. Oncotarget. 2015 Mar 10;6(7):4773-89. doi: 10.18632/oncotarget.3000. Oncotarget. 2015. PMID: 25749382 Free PMC article.

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