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Vascular Protection and Decongestion Without Renin-Angiotensin-Aldosterone System Stimulation Mediated by a Novel Dual-Acting Vasopressin V1a/V2 Receptor Antagonist.
Kolkhof P, Pook E, Pavkovic M, Kretschmer A, Buchmüller A, Tinel H, Delbeck M, Mondritzki T, Wasnaire P, Dinh W, Truebel H, Hüser J, Schmeck C. Kolkhof P, et al. Among authors: kretschmer a. J Cardiovasc Pharmacol. 2019 Jul;74(1):44-52. doi: 10.1097/FJC.0000000000000677. J Cardiovasc Pharmacol. 2019. PMID: 31274842
Discovery of the Soluble Guanylate Cyclase Stimulator Vericiguat (BAY 1021189) for the Treatment of Chronic Heart Failure.
Follmann M, Ackerstaff J, Redlich G, Wunder F, Lang D, Kern A, Fey P, Griebenow N, Kroh W, Becker-Pelster EM, Kretschmer A, Geiss V, Li V, Straub A, Mittendorf J, Jautelat R, Schirok H, Schlemmer KH, Lustig K, Gerisch M, Knorr A, Tinel H, Mondritzki T, Trübel H, Sandner P, Stasch JP. Follmann M, et al. Among authors: kretschmer a. J Med Chem. 2017 Jun 22;60(12):5146-5161. doi: 10.1021/acs.jmedchem.7b00449. Epub 2017 Jun 12. J Med Chem. 2017. PMID: 28557445 Free article.
Runcaciguat, a novel soluble guanylate cyclase activator, shows renoprotection in hypertensive, diabetic, and metabolic preclinical models of chronic kidney disease.
Bénardeau A, Kahnert A, Schomber T, Meyer J, Pavkovic M, Kretschmer A, Lawrenz B, Hartmann E, Mathar I, Hueser J, Kraehling JR, Eitner F, Hahn MG, Stasch JP, Sandner P. Bénardeau A, et al. Among authors: kretschmer a. Naunyn Schmiedebergs Arch Pharmacol. 2021 Dec;394(12):2363-2379. doi: 10.1007/s00210-021-02149-4. Epub 2021 Sep 22. Naunyn Schmiedebergs Arch Pharmacol. 2021. PMID: 34550407 Free PMC article.
Novel heterocyclic thyromimetics.
Haning H, Woltering M, Mueller U, Schmidt G, Schmeck C, Voehringer V, Kretschmer A, Pernerstorfer J. Haning H, et al. Among authors: kretschmer a. Bioorg Med Chem Lett. 2005 Apr 1;15(7):1835-40. doi: 10.1016/j.bmcl.2005.02.028. Bioorg Med Chem Lett. 2005. PMID: 15780617
Novel heterocyclic thyromimetics. Part 2.
Haning H, Mueller U, Schmidt G, Schmeck C, Voehringer V, Kretschmer A, Bischoff H. Haning H, et al. Among authors: kretschmer a. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3992-6. doi: 10.1016/j.bmcl.2007.04.085. Epub 2007 Apr 29. Bioorg Med Chem Lett. 2007. PMID: 17499989
Urinary cGMP predicts major adverse renal events in patients with mild renal impairment and/or diabetes mellitus before exposure to contrast medium.
Chaykovska L, Heunisch F, von Einem G, Hocher CF, Tsuprykov O, Pavkovic M, Sandner P, Kretschmer A, Chu C, Elitok S, Stasch JP, Hocher B. Chaykovska L, et al. Among authors: kretschmer a. PLoS One. 2018 Apr 12;13(4):e0195828. doi: 10.1371/journal.pone.0195828. eCollection 2018. PLoS One. 2018. PMID: 29649334 Free PMC article.
Nitric oxide-sensitive guanylyl cyclase stimulation improves experimental heart failure with preserved ejection fraction.
Wilck N, Markó L, Balogh A, Kräker K, Herse F, Bartolomaeus H, Szijártó IA, Gollasch M, Reichhart N, Strauss O, Heuser A, Brockschnieder D, Kretschmer A, Lesche R, Sohler F, Stasch JP, Sandner P, Luft FC, Müller DN, Dechend R, Haase N. Wilck N, et al. Among authors: kretschmer a. JCI Insight. 2018 Feb 22;3(4):e96006. doi: 10.1172/jci.insight.96006. eCollection 2018 Feb 22. JCI Insight. 2018. PMID: 29467337 Free PMC article.
281 results