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Page 1
Phenotype onset in Huntington's disease knock-in mice is correlated with the incomplete splicing of the mutant huntingtin gene.
Franich NR, Hickey MA, Zhu C, Osborne GF, Ali N, Chu T, Bove NH, Lemesre V, Lerner RP, Zeitlin SO, Howland D, Neueder A, Landles C, Bates GP, Chesselet MF. Franich NR, et al. Among authors: osborne gf. J Neurosci Res. 2019 Dec;97(12):1590-1605. doi: 10.1002/jnr.24493. Epub 2019 Jul 7. J Neurosci Res. 2019. PMID: 31282030 Free PMC article.
HDAC4 does not act as a protein deacetylase in the postnatal murine brain in vivo.
Mielcarek M, Seredenina T, Stokes MP, Osborne GF, Landles C, Inuabasi L, Franklin SA, Silva JC, Luthi-Carter R, Beaumont V, Bates GP. Mielcarek M, et al. Among authors: osborne gf. PLoS One. 2013 Nov 22;8(11):e80849. doi: 10.1371/journal.pone.0080849. eCollection 2013. PLoS One. 2013. PMID: 24278330 Free PMC article.
HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration.
Mielcarek M, Landles C, Weiss A, Bradaia A, Seredenina T, Inuabasi L, Osborne GF, Wadel K, Touller C, Butler R, Robertson J, Franklin SA, Smith DL, Park L, Marks PA, Wanker EE, Olson EN, Luthi-Carter R, van der Putten H, Beaumont V, Bates GP. Mielcarek M, et al. Among authors: osborne gf. PLoS Biol. 2013 Nov;11(11):e1001717. doi: 10.1371/journal.pbio.1001717. Epub 2013 Nov 26. PLoS Biol. 2013. PMID: 24302884 Free PMC article.
Genetic deletion of transglutaminase 2 does not rescue the phenotypic deficits observed in R6/2 and zQ175 mouse models of Huntington's disease.
Menalled LB, Kudwa AE, Oakeshott S, Farrar A, Paterson N, Filippov I, Miller S, Kwan M, Olsen M, Beltran J, Torello J, Fitzpatrick J, Mushlin R, Cox K, McConnell K, Mazzella M, He D, Osborne GF, Al-Nackkash R, Bates GP, Tuunanen P, Lehtimaki K, Brunner D, Ghavami A, Ramboz S, Park L, Macdonald D, Munoz-Sanjuan I, Howland D. Menalled LB, et al. Among authors: osborne gf. PLoS One. 2014 Jun 23;9(6):e99520. doi: 10.1371/journal.pone.0099520. eCollection 2014. PLoS One. 2014. PMID: 24955833 Free PMC article.
Dysfunction of the CNS-heart axis in mouse models of Huntington's disease.
Mielcarek M, Inuabasi L, Bondulich MK, Muller T, Osborne GF, Franklin SA, Smith DL, Neueder A, Rosinski J, Rattray I, Protti A, Bates GP. Mielcarek M, et al. Among authors: osborne gf. PLoS Genet. 2014 Aug 7;10(8):e1004550. doi: 10.1371/journal.pgen.1004550. eCollection 2014 Aug. PLoS Genet. 2014. PMID: 25101683 Free PMC article.
UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome.
Hjerpe R, Bett JS, Keuss MJ, Solovyova A, McWilliams TG, Johnson C, Sahu I, Varghese J, Wood N, Wightman M, Osborne G, Bates GP, Glickman MH, Trost M, Knebel A, Marchesi F, Kurz T. Hjerpe R, et al. Cell. 2016 Aug 11;166(4):935-949. doi: 10.1016/j.cell.2016.07.001. Epub 2016 Jul 28. Cell. 2016. PMID: 27477512 Free PMC article.
Myostatin inhibition prevents skeletal muscle pathophysiology in Huntington's disease mice.
Bondulich MK, Jolinon N, Osborne GF, Smith EJ, Rattray I, Neueder A, Sathasivam K, Ahmed M, Ali N, Benjamin AC, Chang X, Dick JRT, Ellis M, Franklin SA, Goodwin D, Inuabasi L, Lazell H, Lehar A, Richard-Londt A, Rosinski J, Smith DL, Wood T, Tabrizi SJ, Brandner S, Greensmith L, Howland D, Munoz-Sanjuan I, Lee SJ, Bates GP. Bondulich MK, et al. Among authors: osborne gf. Sci Rep. 2017 Oct 27;7(1):14275. doi: 10.1038/s41598-017-14290-3. Sci Rep. 2017. PMID: 29079832 Free PMC article.
Meso scale discovery-based assays for the detection of aggregated huntingtin.
Reindl W, Baldo B, Schulz J, Janack I, Lindner I, Kleinschmidt M, Sedaghat Y, Thiede C, Tillack K, Schmidt C, Cardaun I, Schwagarus T, Herrmann F, Hotze M, Osborne GF, Herrmann S, Weiss A, Zerbinatti C, Bates GP, Bard J, Munoz-Sanjuan I, Macdonald D. Reindl W, et al. Among authors: osborne gf. PLoS One. 2019 Mar 26;14(3):e0213521. doi: 10.1371/journal.pone.0213521. eCollection 2019. PLoS One. 2019. PMID: 30913220 Free PMC article.
Subcellular Localization And Formation Of Huntingtin Aggregates Correlates With Symptom Onset And Progression In A Huntington'S Disease Model.
Landles C, Milton RE, Ali N, Flomen R, Flower M, Schindler F, Gomez-Paredes C, Bondulich MK, Osborne GF, Goodwin D, Salsbury G, Benn CL, Sathasivam K, Smith EJ, Tabrizi SJ, Wanker EE, Bates GP. Landles C, et al. Among authors: osborne gf. Brain Commun. 2020 Aug 3;2(2):fcaa066. doi: 10.1093/braincomms/fcaa066. eCollection 2020. Brain Commun. 2020. PMID: 32954323 Free PMC article.
15 results