Krainer AR - Search Results

1

Antisense Oligonucleotide Therapies for Neurodegenerative Diseases.

Bennett CF, Krainer AR, Cleveland DW. Bennett CF, et al. Among authors: krainer ar. Annu Rev Neurosci. 2019 Jul 8;42:385-406. doi: 10.1146/annurev-neuro-070918-050501. Annu Rev Neurosci. 2019. PMID: 31283897 Free PMC article. Review.

2

Enhancement of SMN2 exon 7 inclusion by antisense oligonucleotides targeting the exon.

Hua Y, Vickers TA, Baker BF, Bennett CF, Krainer AR. Hua Y, et al. Among authors: krainer ar. PLoS Biol. 2007 Apr;5(4):e73. doi: 10.1371/journal.pbio.0050073. PLoS Biol. 2007. PMID: 17355180 Free PMC article.

3

Antisense masking of an hnRNP A1/A2 intronic splicing silencer corrects SMN2 splicing in transgenic mice.

Hua Y, Vickers TA, Okunola HL, Bennett CF, Krainer AR. Hua Y, et al. Among authors: krainer ar. Am J Hum Genet. 2008 Apr;82(4):834-48. doi: 10.1016/j.ajhg.2008.01.014. Epub 2008 Mar 27. Am J Hum Genet. 2008. PMID: 18371932 Free PMC article.

4

Antisense correction of SMN2 splicing in the CNS rescues necrosis in a type III SMA mouse model.

Hua Y, Sahashi K, Hung G, Rigo F, Passini MA, Bennett CF, Krainer AR. Hua Y, et al. Among authors: krainer ar. Genes Dev. 2010 Aug 1;24(15):1634-44. doi: 10.1101/gad.1941310. Epub 2010 Jul 12. Genes Dev. 2010. PMID: 20624852 Free PMC article.

5

Antisense oligonucleotides delivered to the mouse CNS ameliorate symptoms of severe spinal muscular atrophy.

Passini MA, Bu J, Richards AM, Kinnecom C, Sardi SP, Stanek LM, Hua Y, Rigo F, Matson J, Hung G, Kaye EM, Shihabuddin LS, Krainer AR, Bennett CF, Cheng SH. Passini MA, et al. Among authors: krainer ar. Sci Transl Med. 2011 Mar 2;3(72):72ra18. doi: 10.1126/scitranslmed.3001777. Sci Transl Med. 2011. PMID: 21368223 Free PMC article.

6

Peripheral SMN restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model.

Hua Y, Sahashi K, Rigo F, Hung G, Horev G, Bennett CF, Krainer AR. Hua Y, et al. Among authors: krainer ar. Nature. 2011 Oct 5;478(7367):123-6. doi: 10.1038/nature10485. Nature. 2011. PMID: 21979052 Free PMC article.

7

Antisense-mediated exon inclusion.

Hua Y, Krainer AR. Hua Y, et al. Among authors: krainer ar. Methods Mol Biol. 2012;867:307-23. doi: 10.1007/978-1-61779-767-5_20. Methods Mol Biol. 2012. PMID: 22454070 Free PMC article.

8

Synthetic oligonucleotides recruit ILF2/3 to RNA transcripts to modulate splicing.

Rigo F, Hua Y, Chun SJ, Prakash TP, Krainer AR, Bennett CF. Rigo F, et al. Among authors: krainer ar. Nat Chem Biol. 2012 Apr 15;8(6):555-61. doi: 10.1038/nchembio.939. Nat Chem Biol. 2012. PMID: 22504300 Free PMC article.

9

Widespread recognition of 5' splice sites by noncanonical base-pairing to U1 snRNA involving bulged nucleotides.

Roca X, Akerman M, Gaus H, Berdeja A, Bennett CF, Krainer AR. Roca X, et al. Among authors: krainer ar. Genes Dev. 2012 May 15;26(10):1098-109. doi: 10.1101/gad.190173.112. Genes Dev. 2012. PMID: 22588721 Free PMC article.

10

TSUNAMI: an antisense method to phenocopy splicing-associated diseases in animals.

Sahashi K, Hua Y, Ling KK, Hung G, Rigo F, Horev G, Katsuno M, Sobue G, Ko CP, Bennett CF, Krainer AR. Sahashi K, et al. Among authors: krainer ar. Genes Dev. 2012 Aug 15;26(16):1874-84. doi: 10.1101/gad.197418.112. Genes Dev. 2012. PMID: 22895255 Free PMC article.

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