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SCY-078 Is Fungicidal against Candida Species in Time-Kill Studies.
Scorneaux B, Angulo D, Borroto-Esoda K, Ghannoum M, Peel M, Wring S. Scorneaux B, et al. Antimicrob Agents Chemother. 2017 Feb 23;61(3):e01961-16. doi: 10.1128/AAC.01961-16. Print 2017 Mar. Antimicrob Agents Chemother. 2017. PMID: 28069658 Free PMC article.
Preclinical Pharmacokinetics and Pharmacodynamic Target of SCY-078, a First-in-Class Orally Active Antifungal Glucan Synthesis Inhibitor, in Murine Models of Disseminated Candidiasis.
Wring SA, Randolph R, Park S, Abruzzo G, Chen Q, Flattery A, Garrett G, Peel M, Outcalt R, Powell K, Trucksis M, Angulo D, Borroto-Esoda K. Wring SA, et al. Antimicrob Agents Chemother. 2017 Mar 24;61(4):e02068-16. doi: 10.1128/AAC.02068-16. Print 2017 Apr. Antimicrob Agents Chemother. 2017. PMID: 28137806 Free PMC article.
The Emerging Pathogen Candida auris: Growth Phenotype, Virulence Factors, Activity of Antifungals, and Effect of SCY-078, a Novel Glucan Synthesis Inhibitor, on Growth Morphology and Biofilm Formation.
Larkin E, Hager C, Chandra J, Mukherjee PK, Retuerto M, Salem I, Long L, Isham N, Kovanda L, Borroto-Esoda K, Wring S, Angulo D, Ghannoum M. Larkin E, et al. Antimicrob Agents Chemother. 2017 Apr 24;61(5):e02396-16. doi: 10.1128/AAC.02396-16. Print 2017 May. Antimicrob Agents Chemother. 2017. PMID: 28223375 Free PMC article.
Lack of Impact by SCY-078, a First-in-Class Oral Fungicidal Glucan Synthase Inhibitor, on the Pharmacokinetics of Rosiglitazone, a Substrate for CYP450 2C8, Supports the Low Risk for Clinically Relevant Metabolic Drug-Drug Interactions.
Wring S, Murphy G, Atiee G, Corr C, Hyman M, Willett M, Angulo D. Wring S, et al. J Clin Pharmacol. 2018 Oct;58(10):1305-1313. doi: 10.1002/jcph.1146. Epub 2018 May 10. J Clin Pharmacol. 2018. PMID: 29746713 Free PMC article. Clinical Trial.
Topical Treatment for Cutaneous Leishmaniasis: Dermato-Pharmacokinetic Lead Optimization of Benzoxaboroles.
Van Bocxlaer K, Gaukel E, Hauser D, Park SH, Schock S, Yardley V, Randolph R, Plattner JJ, Merchant T, Croft SL, Jacobs RT, Wring SA. Van Bocxlaer K, et al. Among authors: wring sa. Antimicrob Agents Chemother. 2018 Apr 26;62(5):e02419-17. doi: 10.1128/AAC.02419-17. Print 2018 May. Antimicrob Agents Chemother. 2018. PMID: 29507073 Free PMC article.
47 results