AMP-activated protein kinase regulates glycocalyx impairment and macrophage recruitment in response to low shear stress.
Zhang J, Kong X, Wang Z, Gao X, Ge Z, Gu Y, Ye P, Chao Y, Zhu L, Li X, Chen S.
Zhang J, et al. Among authors: kong x.
FASEB J. 2019 Jun;33(6):7202-7212. doi: 10.1096/fj.201801869RRR. Epub 2019 Mar 12.
FASEB J. 2019.
PMID: 30860864
Our results revealed that AMPK dephosphorylation induced by LSS activates NHE1 and HYAL2 to promote HA degradation and glycocalyx injury, which may contribute to endothelial inflammatory reaction and macrophage recruitment.-Zhang, J., Kong, X., Wang, Z., Gao, X …
Our results revealed that AMPK dephosphorylation induced by LSS activates NHE1 and HYAL2 to promote HA degradation and glycocalyx injury, wh …