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Outcompeting p53-Mutant Cells in the Normal Esophagus by Redox Manipulation.
Fernandez-Antoran D, Piedrafita G, Murai K, Ong SH, Herms A, Frezza C, Jones PH. Fernandez-Antoran D, et al. Among authors: frezza c. Cell Stem Cell. 2019 Sep 5;25(3):329-341.e6. doi: 10.1016/j.stem.2019.06.011. Epub 2019 Jul 18. Cell Stem Cell. 2019. PMID: 31327664 Free PMC article.
Organismal metabolism regulates the expansion of oncogenic PIK3CA mutant clones in normal esophagus.
Herms A, Colom B, Piedrafita G, Kalogeropoulou A, Banerjee U, King C, Abby E, Murai K, Caseda I, Fernandez-Antoran D, Ong SH, Hall MWJ, Bryant C, Sood RK, Fowler JC, Pol A, Frezza C, Vanhaesebroeck B, Jones PH. Herms A, et al. Among authors: frezza c. Nat Genet. 2024 Oct;56(10):2144-2157. doi: 10.1038/s41588-024-01891-8. Epub 2024 Aug 21. Nat Genet. 2024. PMID: 39169259 Free PMC article.
Fumarate induces redox-dependent senescence by modifying glutathione metabolism.
Zheng L, Cardaci S, Jerby L, MacKenzie ED, Sciacovelli M, Johnson TI, Gaude E, King A, Leach JD, Edrada-Ebel R, Hedley A, Morrice NA, Kalna G, Blyth K, Ruppin E, Frezza C, Gottlieb E. Zheng L, et al. Among authors: frezza c. Nat Commun. 2015 Jan 23;6:6001. doi: 10.1038/ncomms7001. Nat Commun. 2015. PMID: 25613188 Free PMC article.
Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects.
Tyrakis PA, Yurkovich ME, Sciacovelli M, Papachristou EK, Bridges HR, Gaude E, Schreiner A, D'Santos C, Hirst J, Hernandez-Fernaud J, Springett R, Griffiths JR, Frezza C. Tyrakis PA, et al. Among authors: frezza c. Cell Rep. 2017 Oct 24;21(4):1036-1047. doi: 10.1016/j.celrep.2017.09.092. Cell Rep. 2017. PMID: 29069586 Free PMC article.
242 results