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Glycans flanking the hypervariable connecting peptide between the A and B strands of the V1/V2 domain of HIV-1 gp120 confer resistance to antibodies that neutralize CRF01_AE viruses.
O'Rourke SM, Sutthent R, Phung P, Mesa KA, Frigon NL, To B, Horthongkham N, Limoli K, Wrin T, Berman PW. O'Rourke SM, et al. Among authors: to b. PLoS One. 2015 Mar 20;10(3):e0119608. doi: 10.1371/journal.pone.0119608. eCollection 2015. PLoS One. 2015. PMID: 25793890 Free PMC article.
Understanding the molecular determinants of sensitivity and resistance to neutralizing antibodies is critical for the development of vaccines designed to prevent HIV infection. ...All three mutations created N-linked glycosylation sites (two at N136 and one at N149) …
Understanding the molecular determinants of sensitivity and resistance to neutralizing antibodies is critical for the development of …
59 results