Pillutla RC - Search Results

1

Evaluating a Multiscale Mechanistic Model of the Immune System to Predict Human Immunogenicity for a Biotherapeutic in Phase 1.

Hamuro L, Tirucherai GS, Crawford SM, Nayeem A, Pillutla RC, DeSilva BS, Leil TA, Thalhauser CJ. Hamuro L, et al. Among authors: pillutla rc. AAPS J. 2019 Jul 24;21(5):94. doi: 10.1208/s12248-019-0361-7. AAPS J. 2019. PMID: 31342199 Clinical Trial.

2

Accelerating Regulated Bioanalysis for Biotherapeutics: Case Examples Using a Microfluidic Ligand Binding Assay Platform.

Liu R, Hoffpauir B, Chilewski SD, Gamberdella J, Kavita U, Duo J, Gleason C, Zhang Y, Pillutla R, DeSilva B, Hamuro L. Liu R, et al. AAPS J. 2017 Jan;19(1):82-91. doi: 10.1208/s12248-016-0006-z. Epub 2016 Oct 27. AAPS J. 2017. PMID: 27796911

3

A systematic study of the effect of low pH acid treatment on anti-drug antibodies specific for a domain antibody therapeutic: Impact on drug tolerance, assay sensitivity and post-validation method assessment of ADA in clinical serum samples.

Kavita U, Duo J, Crawford SM, Liu R, Valcin J, Gleason C, Dong H, Gadkari S, Dodge RW, Pillutla RC, DeSilva BS. Kavita U, et al. Among authors: pillutla rc. J Immunol Methods. 2017 Sep;448:91-104. doi: 10.1016/j.jim.2017.06.002. Epub 2017 Jun 16. J Immunol Methods. 2017. PMID: 28625864

4

Rapid development of multiple 'fit-for-purpose' assays on an automatic microfluidic system using a streamlined process in support of early biotherapeutics discovery programs.

Liu R, Pillutla R, DeSilva B, Zhang YJ. Liu R, et al. Bioanalysis. 2013 Jul;5(14):1751-63. doi: 10.4155/bio.13.152. Bioanalysis. 2013. PMID: 23862707

5

Surface plasmon resonance as a tool for ligand-binding assay reagent characterization in bioanalysis of biotherapeutics.

Duo J, Bruno J, Kozhich A, David-Brown D, Luo L, Kwok S, Santockyte R, Haulenbeek J, Liu R, Hamuro L, Peterson JE, Piccoli S, DeSilva B, Pillutla R, Zhang YJ. Duo J, et al. Bioanalysis. 2018 Apr 1;10(8):559-576. doi: 10.4155/bio-2017-0271. Epub 2018 Apr 27. Bioanalysis. 2018. PMID: 29701071

6

Bead-extraction and heat-dissociation (BEHD): A novel way to overcome drug and matrix interference in immunogenicity testing.

Xu W, Sank M, Cummings J, Carl S, Juhel M, Gleason C, Dodge R, DeSilva BS, Kolaitis G, Pillutla R. Xu W, et al. J Immunol Methods. 2018 Nov;462:34-41. doi: 10.1016/j.jim.2018.08.003. Epub 2018 Aug 9. J Immunol Methods. 2018. PMID: 30099014

7

Development and characterization of a pre-treatment procedure to eliminate human monoclonal antibody therapeutic drug and matrix interference in cell-based functional neutralizing antibody assays.

Xu W, Jiang H, Titsch C, Haulenbeek JR, Pillutla RC, Aubry AF, DeSilva BS, Arnold ME, Zeng J, Dodge RW. Xu W, et al. Among authors: pillutla rc. J Immunol Methods. 2015 Jan;416:94-104. doi: 10.1016/j.jim.2014.11.005. Epub 2014 Nov 8. J Immunol Methods. 2015. PMID: 25445325

8

Development and validation of a liquid chromatography tandem mass spectrometry assay for the quantitation of a protein therapeutic in cynomolgus monkey serum.

Zhao Y, Liu G, Angeles A, Hamuro LL, Trouba KJ, Wang B, Pillutla RC, DeSilva BS, Arnold ME, Shen JX. Zhao Y, et al. Among authors: pillutla rc. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Apr 15;988:81-7. doi: 10.1016/j.jchromb.2015.02.007. Epub 2015 Feb 16. J Chromatogr B Analyt Technol Biomed Life Sci. 2015. PMID: 25756208

9

A Fit-for-Purpose Method for the Detection of Human Antibodies to Surface-Exposed Components of BMS-986263, a Lipid Nanoparticle-Based Drug Product Containing a siRNA Drug Substance.

Kavita U, Miller W, Ji QC, Pillutla RC. Kavita U, et al. Among authors: pillutla rc. AAPS J. 2019 Jul 22;21(5):92. doi: 10.1208/s12248-019-0360-8. AAPS J. 2019. PMID: 31332587 Clinical Trial.

10

Development and validation of a functional cell-based neutralizing antibody assay for ipilimumab.

Xu W, Cummings J, Sank M, Juhel M, Li X, Gleason C, DeSilva BS, Dodge RW, Pillutla R. Xu W, et al. Bioanalysis. 2018 Aug 1;10(16):1273-1287. doi: 10.4155/bio-2018-0109. Epub 2018 Jun 27. Bioanalysis. 2018. PMID: 29947549

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