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High Affinity Inhibitors of the Macrophage Infectivity Potentiator Protein from Trypanosoma cruzi, Burkholderia pseudomallei, and Legionella pneumophila─A Comparison.
Lohr T, Herbst C, Bzdyl NM, Jenkins C, Scheuplein NJ, Sugiarto WO, Whittaker JJ, Guskov A, Norville I, Hellmich UA, Hausch F, Sarkar-Tyson M, Sotriffer C, Holzgrabe U. Lohr T, et al. ACS Infect Dis. 2024 Oct 11;10(10):3681-3691. doi: 10.1021/acsinfecdis.4c00553. Epub 2024 Oct 2. ACS Infect Dis. 2024. PMID: 39357850
Evaluating the druggability of TrmD, a potential antibacterial target, through design and microbiological profiling of a series of potent TrmD inhibitors.
Wilkinson AJ, Ooi N, Finlayson J, Lee VE, Lyth D, Maskew KS, Newman R, Orr D, Ansell K, Birchall K, Canning P, Coombs P, Fusani L, McIver E, Pisco J, Ireland PM, Jenkins C, Norville IH, Southern SJ, Cowan R, Hall G, Kettleborough C, Savage VJ, Cooper IR. Wilkinson AJ, et al. Bioorg Med Chem Lett. 2023 Jun 15;90:129331. doi: 10.1016/j.bmcl.2023.129331. Epub 2023 May 13. Bioorg Med Chem Lett. 2023. PMID: 37187252 Free article.
Macrophage infectivity potentiator protein, a peptidyl prolyl cis-trans isomerase, essential for Coxiella burnetii growth and pathogenesis.
Debowski AW, Bzdyl NM, Thomas DR, Scott NE, Jenkins CH, Iwasaki J, Kibble EA, Khoo CA, Scheuplein NJ, Seibel PM, Lohr T, Metters G, Bond CS, Norville IH, Stubbs KA, Harmer NJ, Holzgrabe U, Newton HJ, Sarkar-Tyson M. Debowski AW, et al. Among authors: jenkins ch. PLoS Pathog. 2023 Jul 3;19(7):e1011491. doi: 10.1371/journal.ppat.1011491. eCollection 2023 Jul. PLoS Pathog. 2023. PMID: 37399210 Free PMC article.
27 results