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A series of potent CREBBP bromodomain ligands reveals an induced-fit pocket stabilized by a cation-π interaction.
Rooney TP, Filippakopoulos P, Fedorov O, Picaud S, Cortopassi WA, Hay DA, Martin S, Tumber A, Rogers CM, Philpott M, Wang M, Thompson AL, Heightman TD, Pryde DC, Cook A, Paton RS, Müller S, Knapp S, Brennan PE, Conway SJ. Rooney TP, et al. Among authors: conway sj. Angew Chem Int Ed Engl. 2014 Jun 10;53(24):6126-30. doi: 10.1002/anie.201402750. Epub 2014 May 12. Angew Chem Int Ed Engl. 2014. PMID: 24821300 Free PMC article.
Controlling Intramolecular Interactions in the Design of Selective, High-Affinity Ligands for the CREBBP Bromodomain.
Brand M, Clayton J, Moroglu M, Schiedel M, Picaud S, Bluck JP, Skwarska A, Bolland H, Chan AKN, Laurin CMC, Scorah AR, See L, Rooney TPC, Andrews KH, Fedorov O, Perell G, Kalra P, Vinh KB, Cortopassi WA, Heitel P, Christensen KE, Cooper RI, Paton RS, Pomerantz WCK, Biggin PC, Hammond EM, Filippakopoulos P, Conway SJ. Brand M, et al. Among authors: conway sj. J Med Chem. 2021 Jul 22;64(14):10102-10123. doi: 10.1021/acs.jmedchem.1c00348. Epub 2021 Jul 13. J Med Chem. 2021. PMID: 34255515 Free PMC article.
Wavelength-orthogonal photolysis of neurotransmitters in vitro.
Stanton-Humphreys MN, Taylor RD, McDougall C, Hart ML, Brown CT, Emptage NJ, Conway SJ. Stanton-Humphreys MN, et al. Among authors: conway sj. Chem Commun (Camb). 2012 Jan 18;48(5):657-9. doi: 10.1039/c1cc15135e. Epub 2011 Oct 7. Chem Commun (Camb). 2012. PMID: 21980596
Hypoxia-Activated, Small-Molecule-Induced Gene Expression.
Collins SL, Saha J, Bouchez LC, Hammond EM, Conway SJ. Collins SL, et al. Among authors: conway sj. ACS Chem Biol. 2018 Dec 21;13(12):3354-3360. doi: 10.1021/acschembio.8b00858. Epub 2018 Dec 7. ACS Chem Biol. 2018. PMID: 30451487
Synthesis and biological evaluation of phosphatidylinositol phosphate affinity probes.
Conway SJ, Gardiner J, Grove SJ, Johns MK, Lim ZY, Painter GF, Robinson DE, Schieber C, Thuring JW, Wong LS, Yin MX, Burgess AW, Catimel B, Hawkins PT, Ktistakis NT, Stephens LR, Holmes AB. Conway SJ, et al. Org Biomol Chem. 2010 Jan 7;8(1):66-76. doi: 10.1039/b913399b. Epub 2009 Nov 9. Org Biomol Chem. 2010. PMID: 20024134
339 results