Doughty L - Search Results

1

Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes Aβ Phagocytosis.

Miles LA, Hermans SJ, Crespi GAN, Gooi JH, Doughty L, Nero TL, Markulić J, Ebneth A, Wroblowski B, Oehlrich D, Trabanco AA, Rives ML, Royaux I, Hancock NC, Parker MW. Miles LA, et al. Among authors: doughty l. iScience. 2019 Sep 27;19:110-118. doi: 10.1016/j.isci.2019.07.023. Epub 2019 Jul 19. iScience. 2019. PMID: 31369984 Free PMC article.

2

Manipulating the Lewis antigen specificity of the cholesterol-dependent cytolysin lectinolysin.

Lawrence SL, Feil SC, Holien JK, Kuiper MJ, Doughty L, Dolezal O, Mulhern TD, Tweten RK, Parker MW. Lawrence SL, et al. Among authors: doughty l. Front Immunol. 2012 Nov 5;3:330. doi: 10.3389/fimmu.2012.00330. eCollection 2012. Front Immunol. 2012. PMID: 23181061 Free PMC article.

3

Bapineuzumab captures the N-terminus of the Alzheimer's disease amyloid-beta peptide in a helical conformation.

Miles LA, Crespi GA, Doughty L, Parker MW. Miles LA, et al. Among authors: doughty l. Sci Rep. 2013;3:1302. doi: 10.1038/srep01302. Sci Rep. 2013. PMID: 23416764 Free PMC article.

4

Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA.

Ascher DB, Wielens J, Nero TL, Doughty L, Morton CJ, Parker MW. Ascher DB, et al. Among authors: doughty l. Sci Rep. 2014 Apr 23;4:4765. doi: 10.1038/srep04765. Sci Rep. 2014. PMID: 24755925 Free PMC article.

5

Determinants of oligosaccharide specificity of the carbohydrate-binding modules of AMP-activated protein kinase.

Mobbs JI, Koay A, Di Paolo A, Bieri M, Petrie EJ, Gorman MA, Doughty L, Parker MW, Stapleton DI, Griffin MD, Gooley PR. Mobbs JI, et al. Among authors: doughty l. Biochem J. 2015 Jun 1;468(2):245-57. doi: 10.1042/BJ20150270. Biochem J. 2015. PMID: 25774984

6

Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface.

Koach J, Holien JK, Massudi H, Carter DR, Ciampa OC, Herath M, Lim T, Seneviratne JA, Milazzo G, Murray JE, McCarroll JA, Liu B, Mayoh C, Keenan B, Stevenson BW, Gorman MA, Bell JL, Doughty L, Hüttelmaier S, Oberthuer A, Fischer M, Gifford AJ, Liu T, Zhang X, Zhu S, Gustafson WC, Haber M, Norris MD, Fletcher JI, Perini G, Parker MW, Cheung BB, Marshall GM. Koach J, et al. Among authors: doughty l. Cancer Res. 2019 Nov 1;79(21):5652-5667. doi: 10.1158/0008-5472.CAN-19-1112. Epub 2019 Sep 9. Cancer Res. 2019. PMID: 31501192

7

Structures of the interleukin 11 signalling complex reveal gp130 dynamics and the inhibitory mechanism of a cytokine variant.

Metcalfe RD, Hanssen E, Fung KY, Aizel K, Kosasih CC, Zlatic CO, Doughty L, Morton CJ, Leis AP, Parker MW, Gooley PR, Putoczki TL, Griffin MDW. Metcalfe RD, et al. Among authors: doughty l. Nat Commun. 2023 Nov 20;14(1):7543. doi: 10.1038/s41467-023-42754-w. Nat Commun. 2023. PMID: 37985757 Free PMC article.

8

Combination of bazedoxifene with chemotherapy and SMAC-mimetics for the treatment of colorectal cancer.

Dmello RS, Palmieri M, Thilakasiri PS, Doughty L, Nero TL, Poh AR, To SQ, Lee EF, Douglas Fairlie W, Mielke L, Parker MW, Poon IKH, Batlle E, Ernst M, Chand AL. Dmello RS, et al. Among authors: doughty l. Cell Death Dis. 2024 Apr 10;15(4):255. doi: 10.1038/s41419-024-06631-8. Cell Death Dis. 2024. PMID: 38600086 Free PMC article.

9

Single-chain Fv multimers of the anti-neuraminidase antibody NC10: the residue at position 15 in the V(L) domain of the scFv-0 (V(L)-V(H)) molecule is primarily responsible for formation of a tetramer-trimer equilibrium.

Dolezal O, De Gori R, Walter M, Doughty L, Hattarki M, Hudson PJ, Kortt AA. Dolezal O, et al. Among authors: doughty l. Protein Eng. 2003 Jan;16(1):47-56. doi: 10.1093/proeng/gzg006. Protein Eng. 2003. PMID: 12646692

10

Structural model for the interaction of a designed Ankyrin Repeat Protein with the human epidermal growth factor receptor 2.

Epa VC, Dolezal O, Doughty L, Xiao X, Jost C, Plückthun A, Adams TE. Epa VC, et al. Among authors: doughty l. PLoS One. 2013;8(3):e59163. doi: 10.1371/journal.pone.0059163. Epub 2013 Mar 19. PLoS One. 2013. PMID: 23527120 Free PMC article.

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