Koblan KS - Search Results

1

SEP-363856, a Novel Psychotropic Agent with a Unique, Non-D₂ Receptor Mechanism of Action.

Dedic N, Jones PG, Hopkins SC, Lew R, Shao L, Campbell JE, Spear KL, Large TH, Campbell UC, Hanania T, Leahy E, Koblan KS. Dedic N, et al. Among authors: koblan ks. J Pharmacol Exp Ther. 2019 Oct;371(1):1-14. doi: 10.1124/jpet.119.260281. Epub 2019 Aug 1. J Pharmacol Exp Ther. 2019. PMID: 31371483

2

Effect of TAAR1/5-HT_1A agonist SEP-363856 on REM sleep in humans.

Hopkins SC, Dedic N, Koblan KS. Hopkins SC, et al. Among authors: koblan ks. Transl Psychiatry. 2021 Apr 20;11(1):228. doi: 10.1038/s41398-021-01331-9. Transl Psychiatry. 2021. PMID: 33879769 Free PMC article. Clinical Trial.

3

Discovery of Nonracemic Amisulpride to Maximize Benefit/Risk of 5-HT7 and D2 Receptor Antagonism for the Treatment of Mood Disorders.

Hopkins SC, Wilkinson S, Corriveau TJ, Nishikawa H, Nakamichi K, Loebel A, Koblan KS. Hopkins SC, et al. Among authors: koblan ks. Clin Pharmacol Ther. 2021 Sep;110(3):808-815. doi: 10.1002/cpt.2282. Epub 2021 Jun 12. Clin Pharmacol Ther. 2021. PMID: 33961287 Free PMC article. Clinical Trial.

4

A Non-D2-Receptor-Binding Drug for the Treatment of Schizophrenia.

Koblan KS, Kent J, Hopkins SC, Krystal JH, Cheng H, Goldman R, Loebel A. Koblan KS, et al. N Engl J Med. 2020 Apr 16;382(16):1497-1506. doi: 10.1056/NEJMoa1911772. N Engl J Med. 2020. PMID: 32294346 Clinical Trial.

5

Population pharmacokinetic analysis of ulotaront in subjects with schizophrenia.

Galluppi GR, Polhamus DG, Fisher JM, Hopkins SC, Koblan KS. Galluppi GR, et al. Among authors: koblan ks. CPT Pharmacometrics Syst Pharmacol. 2021 Oct;10(10):1245-1254. doi: 10.1002/psp4.12692. Epub 2021 Aug 10. CPT Pharmacometrics Syst Pharmacol. 2021. PMID: 34292664 Free PMC article.

6

Depicting Safety Profile of TAAR1 Agonist Ulotaront Relative to Reactions Anticipated for a Dopamine D2-Based Pharmacological Class in FAERS.

Hopkins SC, Ogirala A, Worden M, Koblan KS. Hopkins SC, et al. Among authors: koblan ks. Clin Drug Investig. 2021 Dec;41(12):1067-1073. doi: 10.1007/s40261-021-01094-7. Epub 2021 Nov 9. Clin Drug Investig. 2021. PMID: 34751928 Free PMC article. Clinical Trial.

7

Ulotaront, a novel TAAR1 agonist with 5-HT1A agonist activity, lacks abuse liability and attenuates cocaine cue-induced relapse in rats.

Synan C, Bowen C, Heal DJ, Froger-Colléaux C, Beardsley PM, Dedic N, Hopkins SC, Campbell U, Koblan KS. Synan C, et al. Among authors: koblan ks. Drug Alcohol Depend. 2022 Feb 1;231:109261. doi: 10.1016/j.drugalcdep.2021.109261. Epub 2021 Dec 31. Drug Alcohol Depend. 2022. PMID: 35033729 Free article.

8

Ulotaront: A TAAR1 Agonist for the Treatment of Schizophrenia.

Heffernan MLR, Herman LW, Brown S, Jones PG, Shao L, Hewitt MC, Campbell JE, Dedic N, Hopkins SC, Koblan KS, Xie L. Heffernan MLR, et al. Among authors: koblan ks. ACS Med Chem Lett. 2021 Dec 6;13(1):92-98. doi: 10.1021/acsmedchemlett.1c00527. eCollection 2022 Jan 13. ACS Med Chem Lett. 2021. PMID: 35047111 Free PMC article.

9

Differences in memory function between 5-HT1A receptor genotypes in patients with major depressive disorder.

Wesnes KA, Hopkins SC, Brooker HJ, Koblan KS. Wesnes KA, et al. Among authors: koblan ks. CNS Spectr. 2016 Oct;21(5):379-384. doi: 10.1017/S1092852915000802. Epub 2016 Jan 19. CNS Spectr. 2016. PMID: 26780922

10

Transformed PANSS Factors Intended to Reduce Pseudospecificity Among Symptom Domains and Enhance Understanding of Symptom Change in Antipsychotic-Treated Patients With Schizophrenia.

Hopkins SC, Ogirala A, Loebel A, Koblan KS. Hopkins SC, et al. Among authors: koblan ks. Schizophr Bull. 2018 Apr 6;44(3):593-602. doi: 10.1093/schbul/sbx101. Schizophr Bull. 2018. PMID: 28981857 Free PMC article.

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