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Hypothalamic mTORC2 is essential for metabolic health and longevity.
Chellappa K, Brinkman JA, Mukherjee S, Morrison M, Alotaibi MI, Carbajal KA, Alhadeff AL, Perron IJ, Yao R, Purdy CS, DeFelice DM, Wakai MH, Tomasiewicz J, Lin A, Meyer E, Peng Y, Arriola Apelo SI, Puglielli L, Betley JN, Paschos GK, Baur JA, Lamming DW. Chellappa K, et al. Aging Cell. 2019 Oct;18(5):e13014. doi: 10.1111/acel.13014. Epub 2019 Aug 1. Aging Cell. 2019. PMID: 31373126 Free PMC article.
Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle.
Frederick DW, Loro E, Liu L, Davila A Jr, Chellappa K, Silverman IM, Quinn WJ 3rd, Gosai SJ, Tichy ED, Davis JG, Mourkioti F, Gregory BD, Dellinger RW, Redpath P, Migaud ME, Nakamaru-Ogiso E, Rabinowitz JD, Khurana TS, Baur JA. Frederick DW, et al. Among authors: chellappa k. Cell Metab. 2016 Aug 9;24(2):269-82. doi: 10.1016/j.cmet.2016.07.005. Cell Metab. 2016. PMID: 27508874 Free PMC article.
Nicotinamide adenine dinucleotide biosynthesis promotes liver regeneration.
Mukherjee S, Chellappa K, Moffitt A, Ndungu J, Dellinger RW, Davis JG, Agarwal B, Baur JA. Mukherjee S, et al. Among authors: chellappa k. Hepatology. 2017 Feb;65(2):616-630. doi: 10.1002/hep.28912. Epub 2016 Dec 24. Hepatology. 2017. PMID: 27809334 Free PMC article.
Quantitative Analysis of NAD Synthesis-Breakdown Fluxes.
Liu L, Su X, Quinn WJ 3rd, Hui S, Krukenberg K, Frederick DW, Redpath P, Zhan L, Chellappa K, White E, Migaud M, Mitchison TJ, Baur JA, Rabinowitz JD. Liu L, et al. Among authors: chellappa k. Cell Metab. 2018 May 1;27(5):1067-1080.e5. doi: 10.1016/j.cmet.2018.03.018. Cell Metab. 2018. PMID: 29685734 Free PMC article.
mTORC1 restrains adipocyte lipolysis to prevent systemic hyperlipidemia.
Paolella LM, Mukherjee S, Tran CM, Bellaver B, Hugo M, Luongo TS, Shewale SV, Lu W, Chellappa K, Baur JA. Paolella LM, et al. Among authors: chellappa k. Mol Metab. 2020 Feb;32:136-147. doi: 10.1016/j.molmet.2019.12.003. Epub 2019 Dec 13. Mol Metab. 2020. PMID: 32029223 Free PMC article.
Age-related NAD+ decline.
McReynolds MR, Chellappa K, Baur JA. McReynolds MR, et al. Among authors: chellappa k. Exp Gerontol. 2020 Feb 22;134:110888. doi: 10.1016/j.exger.2020.110888. Online ahead of print. Exp Gerontol. 2020. PMID: 32097708 Free PMC article. Review.
31 results