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Immuno-PET identifies the myeloid compartment as a key contributor to the outcome of the antitumor response under PD-1 blockade.
Rashidian M, LaFleur MW, Verschoor VL, Dongre A, Zhang Y, Nguyen TH, Kolifrath S, Aref AR, Lau CJ, Paweletz CP, Bu X, Freeman GJ, Barrasa MI, Weinberg RA, Sharpe AH, Ploegh HL. Rashidian M, et al. Among authors: nguyen th. Proc Natl Acad Sci U S A. 2019 Aug 20;116(34):16971-16980. doi: 10.1073/pnas.1905005116. Epub 2019 Aug 2. Proc Natl Acad Sci U S A. 2019. PMID: 31375632 Free PMC article.
LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade.
Sheng W, LaFleur MW, Nguyen TH, Chen S, Chakravarthy A, Conway JR, Li Y, Chen H, Yang H, Hsu PH, Van Allen EM, Freeman GJ, De Carvalho DD, He HH, Sharpe AH, Shi Y. Sheng W, et al. Among authors: nguyen th. Cell. 2018 Jul 26;174(3):549-563.e19. doi: 10.1016/j.cell.2018.05.052. Epub 2018 Jun 21. Cell. 2018. PMID: 29937226 Free PMC article.
A CRISPR-Cas9 delivery system for in vivo screening of genes in the immune system.
LaFleur MW, Nguyen TH, Coxe MA, Yates KB, Trombley JD, Weiss SA, Brown FD, Gillis JE, Coxe DJ, Doench JG, Haining WN, Sharpe AH. LaFleur MW, et al. Among authors: nguyen th. Nat Commun. 2019 Apr 10;10(1):1668. doi: 10.1038/s41467-019-09656-2. Nat Commun. 2019. PMID: 30971695 Free PMC article.
Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8+ T Cells.
Drijvers JM, Gillis JE, Muijlwijk T, Nguyen TH, Gaudiano EF, Harris IS, LaFleur MW, Ringel AE, Yao CH, Kurmi K, Juneja VR, Trombley JD, Haigis MC, Sharpe AH. Drijvers JM, et al. Among authors: nguyen th. Cancer Immunol Res. 2021 Feb;9(2):184-199. doi: 10.1158/2326-6066.CIR-20-0384. Epub 2020 Dec 4. Cancer Immunol Res. 2021. PMID: 33277233 Free PMC article.
Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity.
Ringel AE, Drijvers JM, Baker GJ, Catozzi A, García-Cañaveras JC, Gassaway BM, Miller BC, Juneja VR, Nguyen TH, Joshi S, Yao CH, Yoon H, Sage PT, LaFleur MW, Trombley JD, Jacobson CA, Maliga Z, Gygi SP, Sorger PK, Rabinowitz JD, Sharpe AH, Haigis MC. Ringel AE, et al. Among authors: nguyen th. Cell. 2020 Dec 23;183(7):1848-1866.e26. doi: 10.1016/j.cell.2020.11.009. Epub 2020 Dec 9. Cell. 2020. PMID: 33301708 Free PMC article.
X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system.
LaFleur MW, Lemmen AM, Streeter ISL, Nguyen TH, Milling LE, Derosia NM, Hoffman ZM, Gillis JE, Tjokrosurjo Q, Markson SC, Huang AY, Anekal PV, Montero Llopis P, Haining WN, Doench JG, Sharpe AH. LaFleur MW, et al. Among authors: nguyen th. Nat Immunol. 2024 Jan;25(1):178-188. doi: 10.1038/s41590-023-01689-6. Epub 2023 Nov 27. Nat Immunol. 2024. PMID: 38012416 Free PMC article.
Framework for in vivo T cell screens.
Milling LE, Markson SC, Tjokrosurjo Q, Derosia NM, Streeter ISL, Hickok GH, Lemmen AM, Nguyen TH, Prathima P, Fithian W, Schwartz MA, Hacohen N, Doench JG, LaFleur MW, Sharpe AH. Milling LE, et al. Among authors: nguyen th. J Exp Med. 2024 Apr 1;221(4):e20230699. doi: 10.1084/jem.20230699. Epub 2024 Feb 27. J Exp Med. 2024. PMID: 38411617 Free PMC article.
Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity.
Georgiev P, Han S, Huang AY, Nguyen TH, Drijvers JM, Creasey H, Pereira JA, Yao CH, Park JS, Conway TS, Fung ME, Liang D, Peluso M, Joshi S, Rowe JH, Miller BC, Freeman GJ, Sharpe AH, Haigis MC, Ringel AE. Georgiev P, et al. Among authors: nguyen th. Cancer Immunol Res. 2024 Nov 4;12(11):1525-1541. doi: 10.1158/2326-6066.CIR-24-0463. Cancer Immunol Res. 2024. PMID: 39186561 Free PMC article.
Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control.
Weiss SA, Huang AY, Fung ME, Martinez D, Chen ACY, LaSalle TJ, Miller BC, Scharer CD, Hegde M, Nguyen TH, Rowe JH, Osborn JF, Patterson DG, Sifnugel N, Mei-An Nolan C, Davidson RA, Schwartz MA, Bally APR, Neeld DK, LaFleur MW, Boss JM, Doench JG, Nicholas Haining W, Sharpe AH, Sen DR. Weiss SA, et al. Among authors: nguyen th. Nat Immunol. 2024 Oct;25(10):1871-1883. doi: 10.1038/s41590-024-01961-3. Epub 2024 Sep 17. Nat Immunol. 2024. PMID: 39289557
2,355 results