Dorsch D - Search Results

1

Discovery and Optimization of 2-Arylquinazolin-4-ones into a Potent and Selective Tankyrase Inhibitor Modulating Wnt Pathway Activity.

Buchstaller HP, Anlauf U, Dorsch D, Kuhn D, Lehmann M, Leuthner B, Musil D, Radtki D, Ritzert C, Rohdich F, Schneider R, Esdar C. Buchstaller HP, et al. Among authors: dorsch d. J Med Chem. 2019 Sep 12;62(17):7897-7909. doi: 10.1021/acs.jmedchem.9b00656. Epub 2019 Aug 20. J Med Chem. 2019. PMID: 31381853

2

Non-peptide angiotensin II receptor antagonists: synthesis and biological activity of a series of novel 4,5-dihydro-4-oxo-3H-imidazo[4,5-c]pyridine derivatives.

Mederski WW, Dorsch D, Bokel HH, Beier N, Lues I, Schelling P. Mederski WW, et al. Among authors: dorsch d. J Med Chem. 1994 May 27;37(11):1632-45. doi: 10.1021/jm00037a014. J Med Chem. 1994. PMID: 8201597

3

Endothelin antagonists: search for surrogates of methylendioxyphenyl by means of a Kohonen neural network.

Anzali S, Mederski WW, Osswald M, Dorsch D. Anzali S, et al. Among authors: dorsch d. Bioorg Med Chem Lett. 1998 Jan 6;8(1):11-6. doi: 10.1016/s0960-894x(97)10150-0. Bioorg Med Chem Lett. 1998. PMID: 9871620

4

Endothelin antagonists: evaluation of 2,1,3-benzothiadiazole as a methylendioxyphenyl bioisoster.

Mederski WW, Osswald M, Dorsch D, Anzali S, Christadler M, Schmitges CJ, Wilm C. Mederski WW, et al. Among authors: dorsch d. Bioorg Med Chem Lett. 1998 Jan 6;8(1):17-22. doi: 10.1016/s0960-894x(97)10151-2. Bioorg Med Chem Lett. 1998. PMID: 9871621

5

Endothelin antagonists: discovery of EMD 122946, a highly potent and orally active ETA selective antagonist.

Mederski WW, Dorsch D, Osswald M, Anzali S, Christadler M, Schmitges CJ, Schelling P, Wilm C, Fluck M. Mederski WW, et al. Among authors: dorsch d. Bioorg Med Chem Lett. 1998 Jul 7;8(13):1771-6. doi: 10.1016/s0960-894x(98)00301-1. Bioorg Med Chem Lett. 1998. PMID: 9873432

6

Benzofuro[3,2-b]pyridines as mixed ET(A)/ET(B) and selective ET(B) endothelin receptor antagonists.

Mederski WW, Osswald M, Dorsch D, Christadler M, Schmitges CJ, Wilm C. Mederski WW, et al. Among authors: dorsch d. Bioorg Med Chem Lett. 1999 Feb 22;9(4):619-22. doi: 10.1016/s0960-894x(99)00040-2. Bioorg Med Chem Lett. 1999. PMID: 10098676

7

Halothiophene benzimidazoles as P1 surrogates of inhibitors of blood coagulation factor Xa.

Mederski WW, Dorsch D, Anzali S, Gleitz J, Cezanne B, Tsaklakidis C. Mederski WW, et al. Among authors: dorsch d. Bioorg Med Chem Lett. 2004 Jul 16;14(14):3763-9. doi: 10.1016/j.bmcl.2004.04.097. Bioorg Med Chem Lett. 2004. PMID: 15203158

8

Chlorothiophenecarboxamides as P1 surrogates of inhibitors of blood coagulation factor Xa.

Mederski WW, Cezanne B, van Amsterdam C, Bühring KU, Dorsch D, Gleitz J, März J, Tsaklakidis C. Mederski WW, et al. Among authors: dorsch d. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5817-22. doi: 10.1016/j.bmcl.2004.09.043. Bioorg Med Chem Lett. 2004. PMID: 15501047

9

Identification and optimization of pyridazinones as potent and selective c-Met kinase inhibitors.

Dorsch D, Schadt O, Stieber F, Meyring M, Grädler U, Bladt F, Friese-Hamim M, Knühl C, Pehl U, Blaukat A. Dorsch D, et al. Bioorg Med Chem Lett. 2015 Apr 1;25(7):1597-602. doi: 10.1016/j.bmcl.2015.02.002. Epub 2015 Feb 16. Bioorg Med Chem Lett. 2015. PMID: 25736998

10

Discovery of novel 7-azaindoles as PDK1 inhibitors.

Wucherer-Plietker M, Merkul E, Müller TJJ, Esdar C, Knöchel T, Heinrich T, Buchstaller HP, Greiner H, Dorsch D, Finsinger D, Calderini M, Bruge D, Grädler U. Wucherer-Plietker M, et al. Among authors: dorsch d. Bioorg Med Chem Lett. 2016 Jul 1;26(13):3073-3080. doi: 10.1016/j.bmcl.2016.05.005. Epub 2016 May 4. Bioorg Med Chem Lett. 2016. PMID: 27217002

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