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Page 1
Impact of CMV Reactivation, Treatment Approaches, and Immune Reconstitution in a Nonmyeloablative Tolerance Induction Protocol in Cynomolgus Macaques.
Alonso-Guallart P, Duran-Struuck R, Zitsman JS, Sameroff S, Pereira M, Stern J, Berglund E, Llore N, Pierre G, Lopes E, Kofman SB, Danton M, Sondermeijer HP, Woodland D, Kato Y, Ekanayake-Alper DK, Iuga AC, Wuu CS, Wu A, Lipkin WI, Tokarz R, Sykes M, Griesemer A. Alonso-Guallart P, et al. Among authors: ekanayake alper dk. Transplantation. 2020 Feb;104(2):270-279. doi: 10.1097/TP.0000000000002893. Transplantation. 2020. PMID: 31385931 Free PMC article.
GalT-KO pig lungs are highly susceptible to acute vascular rejection in baboons, which may be mitigated by transgenic expression of hCD47 on porcine blood vessels.
Watanabe H, Sahara H, Nomura S, Tanabe T, Ekanayake-Alper DK, Boyd LK, Louras NJ, Asfour A, Danton MA, Ho SH, Arn SJ, Hawley RJ, Shimizu A, Nagayasu T, Ayares D, Lorber MI, Sykes M, Sachs DH, Yamada K. Watanabe H, et al. Among authors: ekanayake alper dk. Xenotransplantation. 2018 Sep;25(5):e12391. doi: 10.1111/xen.12391. Epub 2018 Mar 12. Xenotransplantation. 2018. PMID: 29527745 Free PMC article.
Intra-bone bone marrow transplantation from hCD47 transgenic pigs to baboons prolongs chimerism to >60 days and promotes increased porcine lung transplant survival.
Watanabe H, Ariyoshi Y, Pomposelli T, Takeuchi K, Ekanayake-Alper DK, Boyd LK, Arn SJ, Sahara H, Shimizu A, Ayares D, Lorber MI, Sykes M, Sachs DH, Yamada K. Watanabe H, et al. Among authors: ekanayake alper dk. Xenotransplantation. 2020 Jan;27(1):e12552. doi: 10.1111/xen.12552. Epub 2019 Sep 23. Xenotransplantation. 2020. PMID: 31544995 Free PMC article.
Role of Intrinsic (Graft) Versus Extrinsic (Host) Factors in the Growth of Transplanted Organs Following Allogeneic and Xenogeneic Transplantation.
Tanabe T, Watanabe H, Shah JA, Sahara H, Shimizu A, Nomura S, Asfour A, Danton M, Boyd L, Dardenne Meyers A, Ekanayake-Alper DK, Sachs DH, Yamada K. Tanabe T, et al. Among authors: ekanayake alper dk. Am J Transplant. 2017 Jul;17(7):1778-1790. doi: 10.1111/ajt.14210. Epub 2017 Mar 3. Am J Transplant. 2017. PMID: 28117931 Free PMC article.
Expression of human CD47 in pig glomeruli prevents proteinuria and prolongs graft survival following pig-to-baboon xenotransplantation.
Takeuchi K, Ariyoshi Y, Shimizu A, Okumura Y, Cara-Fuentes G, Garcia GE, Pomposelli T, Watanabe H, Boyd L, Ekanayake-Alper DK, Amarnath D, Sykes M, Sachs DH, Johnson RJ, Yamada K. Takeuchi K, et al. Among authors: ekanayake alper dk. Xenotransplantation. 2021 Nov;28(6):e12708. doi: 10.1111/xen.12708. Epub 2021 Aug 21. Xenotransplantation. 2021. PMID: 34418164 Free PMC article.
Antibody reactivity with new antigens revealed in multi-transgenic triple knockout pigs may cause early loss of pig kidneys in baboons.
Ariyoshi Y, Takeuchi K, Pomposelli T, Ekanayake-Alper DK, Shimizu A, Boyd L, Estime E, Ohta M, Asfour A, Scott Arn J, Ayares D, Lorber M, Sykes M, Sachs D, Yamada K. Ariyoshi Y, et al. Among authors: ekanayake alper dk. Xenotransplantation. 2021 Jan;28(1):e12642. doi: 10.1111/xen.12642. Epub 2020 Sep 9. Xenotransplantation. 2021. PMID: 32909301 Free PMC article.