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Dual peroxisome-proliferator-activated-receptor-α/γ activation inhibits SIRT1-PGC1α axis and causes cardiac dysfunction.
Kalliora C, Kyriazis ID, Oka SI, Lieu MJ, Yue Y, Area-Gomez E, Pol CJ, Tian Y, Mizushima W, Chin A, Scerbo D, Schulze PC, Civelek M, Sadoshima J, Madesh M, Goldberg IJ, Drosatos K. Kalliora C, et al. Among authors: chin a. JCI Insight. 2019 Aug 8;5(17):e129556. doi: 10.1172/jci.insight.129556. JCI Insight. 2019. PMID: 31393858 Free PMC article.
Recruitment of RNA Polymerase II to Metabolic Gene Promoters Is Inhibited in the Failing Heart Possibly Through PGC-1α (Peroxisome Proliferator-Activated Receptor-γ Coactivator-1α) Dysregulation.
Bhat S, Chin A, Shirakabe A, Ikeda Y, Ikeda S, Zhai P, Hsu CP, Sayed D, Abdellatif M, Byun J, Schesing K, Tang F, Tian Y, Babu G, Ralda G, Warren JS, Cho J, Sadoshima J, Oka SI. Bhat S, et al. Among authors: chin a. Circ Heart Fail. 2019 Mar;12(3):e005529. doi: 10.1161/CIRCHEARTFAILURE.118.005529. Circ Heart Fail. 2019. PMID: 30798619 Free PMC article.
Thioredoxin-1 maintains mechanistic target of rapamycin (mTOR) function during oxidative stress in cardiomyocytes.
Oka SI, Hirata T, Suzuki W, Naito D, Chen Y, Chin A, Yaginuma H, Saito T, Nagarajan N, Zhai P, Bhat S, Schesing K, Shao D, Hirabayashi Y, Yodoi J, Sciarretta S, Sadoshima J. Oka SI, et al. Among authors: chin a. J Biol Chem. 2017 Nov 17;292(46):18988-19000. doi: 10.1074/jbc.M117.807735. Epub 2017 Sep 22. J Biol Chem. 2017. PMID: 28939765 Free PMC article.
1,186 results