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Dual peroxisome-proliferator-activated-receptor-α/γ activation inhibits SIRT1-PGC1α axis and causes cardiac dysfunction.
Kalliora C, Kyriazis ID, Oka SI, Lieu MJ, Yue Y, Area-Gomez E, Pol CJ, Tian Y, Mizushima W, Chin A, Scerbo D, Schulze PC, Civelek M, Sadoshima J, Madesh M, Goldberg IJ, Drosatos K. Kalliora C, et al. Among authors: drosatos k. JCI Insight. 2019 Aug 8;5(17):e129556. doi: 10.1172/jci.insight.129556. JCI Insight. 2019. PMID: 31393858 Free PMC article.
Ceramide is a cardiotoxin in lipotoxic cardiomyopathy.
Park TS, Hu Y, Noh HL, Drosatos K, Okajima K, Buchanan J, Tuinei J, Homma S, Jiang XC, Abel ED, Goldberg IJ. Park TS, et al. Among authors: drosatos k. J Lipid Res. 2008 Oct;49(10):2101-12. doi: 10.1194/jlr.M800147-JLR200. Epub 2008 May 30. J Lipid Res. 2008. PMID: 18515784 Free PMC article.
Cardiomyocyte lipids impair β-adrenergic receptor function via PKC activation.
Drosatos K, Bharadwaj KG, Lymperopoulos A, Ikeda S, Khan R, Hu Y, Agarwal R, Yu S, Jiang H, Steinberg SF, Blaner WS, Koch WJ, Goldberg IJ. Drosatos K, et al. Am J Physiol Endocrinol Metab. 2011 Mar;300(3):E489-99. doi: 10.1152/ajpendo.00569.2010. Epub 2010 Dec 7. Am J Physiol Endocrinol Metab. 2011. PMID: 21139071 Free PMC article.
Human aldose reductase expression accelerates atherosclerosis in diabetic apolipoprotein E-/- mice.
Vedantham S, Noh H, Ananthakrishnan R, Son N, Hallam K, Hu Y, Yu S, Shen X, Rosario R, Lu Y, Ravindranath T, Drosatos K, Huggins LA, Schmidt AM, Goldberg IJ, Ramasamy R. Vedantham S, et al. Among authors: drosatos k. Arterioscler Thromb Vasc Biol. 2011 Aug;31(8):1805-13. doi: 10.1161/ATVBAHA.111.226902. Epub 2011 Jun 2. Arterioscler Thromb Vasc Biol. 2011. PMID: 21636809 Free PMC article.
Inhibition of c-Jun-N-terminal kinase increases cardiac peroxisome proliferator-activated receptor alpha expression and fatty acid oxidation and prevents lipopolysaccharide-induced heart dysfunction.
Drosatos K, Drosatos-Tampakaki Z, Khan R, Homma S, Schulze PC, Zannis VI, Goldberg IJ. Drosatos K, et al. Among authors: drosatos tampakaki z. J Biol Chem. 2011 Oct 21;286(42):36331-9. doi: 10.1074/jbc.M111.272146. Epub 2011 Aug 26. J Biol Chem. 2011. PMID: 21873422 Free PMC article.
Ventricular assist device implantation corrects myocardial lipotoxicity, reverses insulin resistance, and normalizes cardiac metabolism in patients with advanced heart failure.
Chokshi A, Drosatos K, Cheema FH, Ji R, Khawaja T, Yu S, Kato T, Khan R, Takayama H, Knöll R, Milting H, Chung CS, Jorde U, Naka Y, Mancini DM, Goldberg IJ, Schulze PC. Chokshi A, et al. Among authors: drosatos k. Circulation. 2012 Jun 12;125(23):2844-53. doi: 10.1161/CIRCULATIONAHA.111.060889. Epub 2012 May 14. Circulation. 2012. PMID: 22586279 Free PMC article.
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