Gut-derived GIP activates central Rap1 to impair neural leptin sensitivity during overnutrition.
Kaneko K, Fu Y, Lin HY, Cordonier EL, Mo Q, Gao Y, Yao T, Naylor J, Howard V, Saito K, Xu P, Chen SS, Chen MH, Xu Y, Williams KW, Ravn P, Fukuda M.
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J Clin Invest. 2019 Aug 12;129(9):3786-3791. doi: 10.1172/JCI126107. eCollection 2019 Aug 12.
J Clin Invest. 2019.
PMID: 31403469
Free PMC article.