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Discovery of N-Substituted 3-Amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic Acids as Highly Potent Third-Generation Inhibitors of Human Arginase I and II.
Van Zandt MC, Jagdmann GE, Whitehouse DL, Ji M, Savoy J, Potapova O, Cousido-Siah A, Mitschler A, Howard EI, Pyle AM, Podjarny AD. Van Zandt MC, et al. Among authors: pyle am. J Med Chem. 2019 Sep 12;62(17):8164-8177. doi: 10.1021/acs.jmedchem.9b00931. Epub 2019 Aug 23. J Med Chem. 2019. PMID: 31408339
A minimal RNA ligand for potent RIG-I activation in living mice.
Linehan MM, Dickey TH, Molinari ES, Fitzgerald ME, Potapova O, Iwasaki A, Pyle AM. Linehan MM, et al. Among authors: pyle am. Sci Adv. 2018 Feb 21;4(2):e1701854. doi: 10.1126/sciadv.1701854. eCollection 2018 Feb. Sci Adv. 2018. PMID: 29492454 Free PMC article.
Small-Molecule Antagonists of the RIG-I Innate Immune Receptor.
Rawling DC, Jagdmann GE Jr, Potapova O, Pyle AM. Rawling DC, et al. Among authors: pyle am. ACS Chem Biol. 2020 Feb 21;15(2):311-317. doi: 10.1021/acschembio.9b00810. Epub 2020 Jan 27. ACS Chem Biol. 2020. PMID: 31944652
226 results