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Wilson disease protein ATP7B utilizes lysosomal exocytosis to maintain copper homeostasis.
Polishchuk EV, Concilli M, Iacobacci S, Chesi G, Pastore N, Piccolo P, Paladino S, Baldantoni D, van IJzendoorn SC, Chan J, Chang CJ, Amoresano A, Pane F, Pucci P, Tarallo A, Parenti G, Brunetti-Pierri N, Settembre C, Ballabio A, Polishchuk RS. Polishchuk EV, et al. Among authors: polishchuk rs. Dev Cell. 2014 Jun 23;29(6):686-700. doi: 10.1016/j.devcel.2014.04.033. Epub 2014 Jun 5. Dev Cell. 2014. PMID: 24909901 Free PMC article.
Identification of p38 MAPK and JNK as new targets for correction of Wilson disease-causing ATP7B mutants.
Chesi G, Hegde RN, Iacobacci S, Concilli M, Parashuraman S, Festa BP, Polishchuk EV, Di Tullio G, Carissimo A, Montefusco S, Canetti D, Monti M, Amoresano A, Pucci P, van de Sluis B, Lutsenko S, Luini A, Polishchuk RS. Chesi G, et al. Among authors: polishchuk ev, polishchuk rs. Hepatology. 2016 Jun;63(6):1842-59. doi: 10.1002/hep.28398. Epub 2016 Jan 25. Hepatology. 2016. PMID: 26660341 Free PMC article.
The emerging role of lysosomes in copper homeostasis.
Polishchuk EV, Polishchuk RS. Polishchuk EV, et al. Among authors: polishchuk rs. Metallomics. 2016 Sep 1;8(9):853-62. doi: 10.1039/c6mt00058d. Epub 2016 Jun 24. Metallomics. 2016. PMID: 27339113 Review.
Activation of Autophagy, Observed in Liver Tissues From Patients With Wilson Disease and From ATP7B-Deficient Animals, Protects Hepatocytes From Copper-Induced Apoptosis.
Polishchuk EV, Merolla A, Lichtmannegger J, Romano A, Indrieri A, Ilyechova EY, Concilli M, De Cegli R, Crispino R, Mariniello M, Petruzzelli R, Ranucci G, Iorio R, Pietrocola F, Einer C, Borchard S, Zibert A, Schmidt HH, Di Schiavi E, Puchkova LV, Franco B, Kroemer G, Zischka H, Polishchuk RS. Polishchuk EV, et al. Among authors: polishchuk rs. Gastroenterology. 2019 Mar;156(4):1173-1189.e5. doi: 10.1053/j.gastro.2018.11.032. Epub 2018 Nov 17. Gastroenterology. 2019. PMID: 30452922
A High-Calorie Diet Aggravates Mitochondrial Dysfunction and Triggers Severe Liver Damage in Wilson Disease Rats.
Einer C, Leitzinger C, Lichtmannegger J, Eberhagen C, Rieder T, Borchard S, Wimmer R, Denk G, Popper B, Neff F, Polishchuk EV, Polishchuk RS, Hauck SM, von Toerne C, Müller JC, Karst U, Baral BS, DiSpirito AA, Kremer AE, Semrau J, Weiss KH, Hohenester S, Zischka H. Einer C, et al. Among authors: polishchuk ev, polishchuk rs. Cell Mol Gastroenterol Hepatol. 2019;7(3):571-596. doi: 10.1016/j.jcmgh.2018.12.005. Epub 2018 Dec 23. Cell Mol Gastroenterol Hepatol. 2019. PMID: 30586623 Free PMC article.
145 results