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Robust Th1 cellular and humoral responses generated by the Yersinia pestis rF1-V subunit vaccine formulated to contain an agonist of the CD137 pathway do not translate into increased protection against pneumonic plague.
Bowen W, Batra L, Pulsifer AR, Yolcu ES, Lawrenz MB, Shirwan H. Bowen W, et al. Among authors: pulsifer ar. Vaccine. 2019 Sep 10;37(38):5708-5716. doi: 10.1016/j.vaccine.2019.07.103. Epub 2019 Aug 12. Vaccine. 2019. PMID: 31416643 Free PMC article.
Yersinia pestis Requires Host Rab1b for Survival in Macrophages.
Connor MG, Pulsifer AR, Price CT, Abu Kwaik Y, Lawrenz MB. Connor MG, et al. Among authors: pulsifer ar. PLoS Pathog. 2015 Oct 23;11(10):e1005241. doi: 10.1371/journal.ppat.1005241. eCollection 2015 Oct. PLoS Pathog. 2015. PMID: 26495854 Free PMC article.
Type 3 secretion system induced leukotriene B4 synthesis by leukocytes is actively inhibited by Yersinia pestis to evade early immune recognition.
Brady A, Sheneman KR, Pulsifer AR, Price SL, Garrison TM, Maddipati KR, Bodduluri SR, Pan J, Boyd NL, Zheng JJ, Rai SN, Hellmann J, Haribabu B, Uriarte SM, Lawrenz MB. Brady A, et al. Among authors: pulsifer ar. PLoS Pathog. 2024 Jan 25;20(1):e1011280. doi: 10.1371/journal.ppat.1011280. eCollection 2024 Jan. PLoS Pathog. 2024. PMID: 38271464 Free PMC article.
Single domain antibodies against enteric pathogen virulence factors are active as curli fiber fusions on probiotic E. coli Nissle 1917.
Gelfat I, Aqeel Y, Tremblay JM, Jaskiewicz JJ, Shrestha A, Lee JN, Hu S, Qian X, Magoun L, Sheoran A, Bedenice D, Giem C, Manjula-Basavanna A, Pulsifer AR, Tu HX, Li X, Minus ML, Osburne MS, Tzipori S, Shoemaker CB, Leong JM, Joshi NS. Gelfat I, et al. Among authors: pulsifer ar. PLoS Pathog. 2022 Sep 15;18(9):e1010713. doi: 10.1371/journal.ppat.1010713. eCollection 2022 Sep. PLoS Pathog. 2022. PMID: 36107831 Free PMC article.