Ulens C - Search Results

1

A Decoy-Receptor Approach Using Nicotinic Acetylcholine Receptor Mimics Reveals Their Potential as Novel Therapeutics Against Neurotoxic Snakebite.

Albulescu LO, Kazandjian T, Slagboom J, Bruyneel B, Ainsworth S, Alsolaiss J, Wagstaff SC, Whiteley G, Harrison RA, Ulens C, Kool J, Casewell NR. Albulescu LO, et al. Among authors: ulens c. Front Pharmacol. 2019 Jul 30;10:848. doi: 10.3389/fphar.2019.00848. eCollection 2019. Front Pharmacol. 2019. PMID: 31417406 Free PMC article.

2

Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms.

Otvos RA, Iyer JK, van Elk R, Ulens C, Niessen WM, Somsen GW, Kini RM, Smit AB, Kool J. Otvos RA, et al. Among authors: ulens c. Toxins (Basel). 2015 Jun 24;7(7):2336-53. doi: 10.3390/toxins7072336. Toxins (Basel). 2015. PMID: 26114334 Free PMC article.

3

The molecular mechanism of snake short-chain α-neurotoxin binding to muscle-type nicotinic acetylcholine receptors.

Nys M, Zarkadas E, Brams M, Mehregan A, Kambara K, Kool J, Casewell NR, Bertrand D, Baenziger JE, Nury H, Ulens C. Nys M, et al. Among authors: ulens c. Nat Commun. 2022 Aug 4;13(1):4543. doi: 10.1038/s41467-022-32174-7. Nat Commun. 2022. PMID: 35927270 Free PMC article.

4

An in vitro assay to investigate venom neurotoxin activity on muscle-type nicotinic acetylcholine receptor activation and for the discovery of toxin-inhibitory molecules.

Patel RN, Clare RH, Ledsgaard L, Nys M, Kool J, Laustsen AH, Ulens C, Casewell NR. Patel RN, et al. Among authors: ulens c. Biochem Pharmacol. 2023 Oct;216:115758. doi: 10.1016/j.bcp.2023.115758. Epub 2023 Aug 20. Biochem Pharmacol. 2023. PMID: 37604290 Free PMC article.

5

Author Correction: The molecular mechanism of snake short-chain α-neurotoxin binding to muscle-type nicotinic acetylcholine receptors.

Nys M, Zarkadas E, Brams M, Mehregan A, Kambara K, Kool J, Casewell NR, Bertrand D, Baenziger JE, Nury H, Ulens C. Nys M, et al. Among authors: ulens c. Nat Commun. 2024 May 28;15(1):4532. doi: 10.1038/s41467-024-48904-y. Nat Commun. 2024. PMID: 38806512 Free PMC article. No abstract available.

6

Use of acetylcholine binding protein in the search for novel alpha7 nicotinic receptor ligands. In silico docking, pharmacological screening, and X-ray analysis.

Ulens C, Akdemir A, Jongejan A, van Elk R, Bertrand S, Perrakis A, Leurs R, Smit AB, Sixma TK, Bertrand D, de Esch IJ. Ulens C, et al. J Med Chem. 2009 Apr 23;52(8):2372-83. doi: 10.1021/jm801400g. J Med Chem. 2009. PMID: 19331415

7

An allosteric binding site of the α7 nicotinic acetylcholine receptor revealed in a humanized acetylcholine-binding protein.

Delbart F, Brams M, Gruss F, Noppen S, Peigneur S, Boland S, Chaltin P, Brandao-Neto J, von Delft F, Touw WG, Joosten RP, Liekens S, Tytgat J, Ulens C. Delbart F, et al. Among authors: ulens c. J Biol Chem. 2018 Feb 16;293(7):2534-2545. doi: 10.1074/jbc.M117.815316. Epub 2017 Dec 13. J Biol Chem. 2018. PMID: 29237730 Free PMC article.

8

Editorial: From Peptide and Protein Toxins to Ion Channel Structure/Function and Drug Design.

Nicke A, Ulens C, Rolland JF, Tsetlin VI. Nicke A, et al. Among authors: ulens c. Front Pharmacol. 2020 Sep 25;11:548366. doi: 10.3389/fphar.2020.548366. eCollection 2020. Front Pharmacol. 2020. PMID: 33101018 Free PMC article. No abstract available.

9

Crystal structures of a cysteine-modified mutant in loop D of acetylcholine-binding protein.

Brams M, Gay EA, Sáez JC, Guskov A, van Elk R, van der Schors RC, Peigneur S, Tytgat J, Strelkov SV, Smit AB, Yakel JL, Ulens C. Brams M, et al. Among authors: ulens c. J Biol Chem. 2011 Feb 11;286(6):4420-8. doi: 10.1074/jbc.M110.188730. Epub 2010 Nov 29. J Biol Chem. 2011. PMID: 21115477 Free PMC article.

10

Molecular actions of smoking cessation drugs at α4β2 nicotinic receptors defined in crystal structures of a homologous binding protein.

Billen B, Spurny R, Brams M, van Elk R, Valera-Kummer S, Yakel JL, Voets T, Bertrand D, Smit AB, Ulens C. Billen B, et al. Among authors: ulens c. Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9173-8. doi: 10.1073/pnas.1116397109. Epub 2012 May 22. Proc Natl Acad Sci U S A. 2012. PMID: 22619328 Free PMC article.

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