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Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and α-Synuclein Proteotoxicity.
Tariq A, Lin J, Jackrel ME, Hesketh CD, Carman PJ, Mack KL, Weitzman R, Gambogi C, Hernandez Murillo OA, Sweeny EA, Gurpinar E, Yokom AL, Gates SN, Yee K, Sudesh S, Stillman J, Rizo AN, Southworth DR, Shorter J. Tariq A, et al. Among authors: gates sn. Cell Rep. 2019 Aug 20;28(8):2080-2095.e6. doi: 10.1016/j.celrep.2019.07.069. Cell Rep. 2019. PMID: 31433984 Free PMC article.
Polyphosphate: A Conserved Modifier of Amyloidogenic Processes.
Cremers CM, Knoefler D, Gates S, Martin N, Dahl JU, Lempart J, Xie L, Chapman MR, Galvan V, Southworth DR, Jakob U. Cremers CM, et al. Mol Cell. 2016 Sep 1;63(5):768-80. doi: 10.1016/j.molcel.2016.07.016. Epub 2016 Aug 25. Mol Cell. 2016. PMID: 27570072 Free PMC article.
Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104.
Gates SN, Yokom AL, Lin J, Jackrel ME, Rizo AN, Kendsersky NM, Buell CE, Sweeny EA, Mack KL, Chuang E, Torrente MP, Su M, Shorter J, Southworth DR. Gates SN, et al. Science. 2017 Jul 21;357(6348):273-279. doi: 10.1126/science.aan1052. Epub 2017 Jun 15. Science. 2017. PMID: 28619716 Free PMC article.
Design principles to tailor Hsp104 therapeutics.
Lin J, Carman PJ, Gambogi CW, Kendsersky NM, Chuang E, Gates SN, Yokom AL, Rizo AN, Southworth DR, Shorter J. Lin J, et al. Among authors: gates sn. bioRxiv [Preprint]. 2024 Apr 28:2024.04.26.591398. doi: 10.1101/2024.04.26.591398. bioRxiv. 2024. PMID: 38712168 Free PMC article. Preprint.
13 results