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Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and α-Synuclein Proteotoxicity.
Tariq A, Lin J, Jackrel ME, Hesketh CD, Carman PJ, Mack KL, Weitzman R, Gambogi C, Hernandez Murillo OA, Sweeny EA, Gurpinar E, Yokom AL, Gates SN, Yee K, Sudesh S, Stillman J, Rizo AN, Southworth DR, Shorter J. Tariq A, et al. Among authors: sweeny ea. Cell Rep. 2019 Aug 20;28(8):2080-2095.e6. doi: 10.1016/j.celrep.2019.07.069. Cell Rep. 2019. PMID: 31433984 Free PMC article.
Purification of hsp104, a protein disaggregase.
Sweeny EA, DeSantis ME, Shorter J. Sweeny EA, et al. J Vis Exp. 2011 Sep 30;(55):3190. doi: 10.3791/3190. J Vis Exp. 2011. PMID: 21989490 Free PMC article.
Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104.
Gates SN, Yokom AL, Lin J, Jackrel ME, Rizo AN, Kendsersky NM, Buell CE, Sweeny EA, Mack KL, Chuang E, Torrente MP, Su M, Shorter J, Southworth DR. Gates SN, et al. Among authors: sweeny ea. Science. 2017 Jul 21;357(6348):273-279. doi: 10.1126/science.aan1052. Epub 2017 Jun 15. Science. 2017. PMID: 28619716 Free PMC article.
Avidity for Polypeptide Binding by Nucleotide-Bound Hsp104 Structures.
Weaver CL, Duran EC, Mack KL, Lin J, Jackrel ME, Sweeny EA, Shorter J, Lucius AL. Weaver CL, et al. Among authors: sweeny ea. Biochemistry. 2017 Apr 18;56(15):2071-2075. doi: 10.1021/acs.biochem.7b00225. Epub 2017 Apr 10. Biochemistry. 2017. PMID: 28379007 Free PMC article.
25 results