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Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and α-Synuclein Proteotoxicity.
Tariq A, Lin J, Jackrel ME, Hesketh CD, Carman PJ, Mack KL, Weitzman R, Gambogi C, Hernandez Murillo OA, Sweeny EA, Gurpinar E, Yokom AL, Gates SN, Yee K, Sudesh S, Stillman J, Rizo AN, Southworth DR, Shorter J. Tariq A, et al. Among authors: yokom al. Cell Rep. 2019 Aug 20;28(8):2080-2095.e6. doi: 10.1016/j.celrep.2019.07.069. Cell Rep. 2019. PMID: 31433984 Free PMC article.
Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104.
Gates SN, Yokom AL, Lin J, Jackrel ME, Rizo AN, Kendsersky NM, Buell CE, Sweeny EA, Mack KL, Chuang E, Torrente MP, Su M, Shorter J, Southworth DR. Gates SN, et al. Among authors: yokom al. Science. 2017 Jul 21;357(6348):273-279. doi: 10.1126/science.aan1052. Epub 2017 Jun 15. Science. 2017. PMID: 28619716 Free PMC article.
A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission.
Flower TG, Takahashi Y, Hudait A, Rose K, Tjahjono N, Pak AJ, Yokom AL, Liang X, Wang HG, Bouamr F, Voth GA, Hurley JH. Flower TG, et al. Among authors: yokom al. Nat Struct Mol Biol. 2020 Jun;27(6):570-580. doi: 10.1038/s41594-020-0426-4. Epub 2020 May 18. Nat Struct Mol Biol. 2020. PMID: 32424346 Free PMC article.
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