Shen J - Search Results

1

Nature brings new avenues to the therapy of central nervous system diseases-An overview of possible treatments derived from natural products.

Zhang J, He Y, Jiang X, Jiang H, Shen J. Zhang J, et al. Among authors: shen j. Sci China Life Sci. 2019 Oct;62(10):1332-1367. doi: 10.1007/s11427-019-9587-y. Epub 2019 Aug 22. Sci China Life Sci. 2019. PMID: 31444682 Review.

2

Molecular modeling on kappa opioid receptor and its interaction with nonpeptide kappa opioid agonists.

Liu DX, Jiang HL, Shen JS, Zhu WL, Zhao L, Chen KX, Ji RY. Liu DX, et al. Among authors: shen js. Zhongguo Yao Li Xue Bao. 1999 Feb;20(2):131-6. Zhongguo Yao Li Xue Bao. 1999. PMID: 10437159 Free article.

3

Brownian dynamics simulations of interaction between scorpion toxin Lq2 and potassium ion channel.

Cui M, Shen J, Briggs JM, Luo X, Tan X, Jiang H, Chen K, Ji R. Cui M, et al. Among authors: shen j. Biophys J. 2001 Apr;80(4):1659-69. doi: 10.1016/S0006-3495(01)76138-3. Biophys J. 2001. PMID: 11259281 Free PMC article.

4

Multiple pharmacophore models combined with molecular docking: a reliable way for efficiently identifying novel PDE4 inhibitors with high structural diversity.

Chen Z, Tian G, Wang Z, Jiang H, Shen J, Zhu W. Chen Z, et al. Among authors: shen j. J Chem Inf Model. 2010 Apr 26;50(4):615-25. doi: 10.1021/ci9004173. J Chem Inf Model. 2010. PMID: 20353193

5

Sildenafil promotes adipogenesis through a PKG pathway.

Zhang X, Ji J, Yan G, Wu J, Sun X, Shen J, Jiang H, Wang H. Zhang X, et al. Among authors: shen j. Biochem Biophys Res Commun. 2010 Jun 11;396(4):1054-9. doi: 10.1016/j.bbrc.2010.05.064. Epub 2010 May 21. Biochem Biophys Res Commun. 2010. PMID: 20471953

6

The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site.

Li Q, Qi J, Zhang W, Vavricka CJ, Shi Y, Wei J, Feng E, Shen J, Chen J, Liu D, He J, Yan J, Liu H, Jiang H, Teng M, Li X, Gao GF. Li Q, et al. Among authors: shen j. Nat Struct Mol Biol. 2010 Oct;17(10):1266-8. doi: 10.1038/nsmb.1909. Epub 2010 Sep 19. Nat Struct Mol Biol. 2010. PMID: 20852645

7

Utilization of halogen bond in lead optimization: a case study of rational design of potent phosphodiesterase type 5 (PDE5) inhibitors.

Xu Z, Liu Z, Chen T, Chen T, Wang Z, Tian G, Shi J, Wang X, Lu Y, Yan X, Wang G, Jiang H, Chen K, Wang S, Xu Y, Shen J, Zhu W. Xu Z, et al. Among authors: shen j. J Med Chem. 2011 Aug 11;54(15):5607-11. doi: 10.1021/jm200644r. Epub 2011 Jul 14. J Med Chem. 2011. PMID: 21714539

8

PDE5 inhibitor promotes melanin synthesis through the PKG pathway in B16 melanoma cells.

Zhang X, Yan G, Ji J, Wu J, Sun X, Shen J, Jiang H, Wang H. Zhang X, et al. Among authors: shen j. J Cell Biochem. 2012 Aug;113(8):2738-43. doi: 10.1002/jcb.24147. J Cell Biochem. 2012. PMID: 22441938

9

Design, synthesis, and pharmacological evaluation of monocyclic pyrimidinones as novel inhibitors of PDE5.

Wang G, Liu Z, Chen T, Wang Z, Yang H, Zheng M, Ren J, Tian G, Yang X, Li L, Li J, Suo J, Zhang R, Jiang X, Terrett NK, Shen J, Xu Y, Jiang H. Wang G, et al. Among authors: shen j. J Med Chem. 2012 Dec 13;55(23):10540-50. doi: 10.1021/jm301159y. Epub 2012 Nov 19. J Med Chem. 2012. PMID: 23137303

10

Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5.

Gong X, Wang G, Ren J, Liu Z, Wang Z, Chen T, Yang X, Jiang X, Shen J, Jiang H, Aisa HA, Xu Y, Li J. Gong X, et al. Among authors: shen j. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4944-7. doi: 10.1016/j.bmcl.2013.06.062. Epub 2013 Jun 29. Bioorg Med Chem Lett. 2013. PMID: 23867165

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