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Many amino acid substitutions in a hypoxia-inducible transcription factor (HIF)-1alpha-like peptide cause only minor changes in its hydroxylation by the HIF prolyl 4-hydroxylases: substitution of 3,4-dehydroproline or azetidine-2-carboxylic acid for the proline leads to a high rate of uncoupled 2-oxoglutarate decarboxylation.
Li D, Hirsilä M, Koivunen P, Brenner MC, Xu L, Yang C, Kivirikko KI, Myllyharju J. Li D, et al. Among authors: myllyharju j. J Biol Chem. 2004 Dec 31;279(53):55051-9. doi: 10.1074/jbc.M410287200. Epub 2004 Oct 12. J Biol Chem. 2004. PMID: 15485863 Free article.
149 results