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Tau-induced mitochondrial membrane perturbation is dependent upon cardiolipin.
Camilleri A, Ghio S, Caruana M, Weckbecker D, Schmidt F, Kamp F, Leonov A, Ryazanov S, Griesinger C, Giese A, Cauchi RJ, Vassallo N. Camilleri A, et al. Among authors: ryazanov s. Biochim Biophys Acta Biomembr. 2020 Feb 1;1862(2):183064. doi: 10.1016/j.bbamem.2019.183064. Epub 2019 Sep 12. Biochim Biophys Acta Biomembr. 2020. PMID: 31521630 Free article.
Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease.
Wagner J, Ryazanov S, Leonov A, Levin J, Shi S, Schmidt F, Prix C, Pan-Montojo F, Bertsch U, Mitteregger-Kretzschmar G, Geissen M, Eiden M, Leidel F, Hirschberger T, Deeg AA, Krauth JJ, Zinth W, Tavan P, Pilger J, Zweckstetter M, Frank T, Bähr M, Weishaupt JH, Uhr M, Urlaub H, Teichmann U, Samwer M, Bötzel K, Groschup M, Kretzschmar H, Griesinger C, Giese A. Wagner J, et al. Among authors: ryazanov s. Acta Neuropathol. 2013 Jun;125(6):795-813. doi: 10.1007/s00401-013-1114-9. Epub 2013 Apr 19. Acta Neuropathol. 2013. PMID: 23604588 Free PMC article.
Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies.
Wagner J, Krauss S, Shi S, Ryazanov S, Steffen J, Miklitz C, Leonov A, Kleinknecht A, Göricke B, Weishaupt JH, Weckbecker D, Reiner AM, Zinth W, Levin J, Ehninger D, Remy S, Kretzschmar HA, Griesinger C, Giese A, Fuhrmann M. Wagner J, et al. Among authors: ryazanov s. Acta Neuropathol. 2015 Nov;130(5):619-31. doi: 10.1007/s00401-015-1483-3. Epub 2015 Oct 6. Acta Neuropathol. 2015. PMID: 26439832 Free PMC article.
Treatment with diphenyl-pyrazole compound anle138b/c reveals that α-synuclein protects melanoma cells from autophagic cell death.
Turriani E, Lázaro DF, Ryazanov S, Leonov A, Giese A, Schön M, Schön MP, Griesinger C, Outeiro TF, Arndt-Jovin DJ, Becker D. Turriani E, et al. Among authors: ryazanov s. Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):E4971-E4977. doi: 10.1073/pnas.1700200114. Epub 2017 Jun 5. Proc Natl Acad Sci U S A. 2017. PMID: 28584093 Free PMC article.
The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology.
Martinez Hernandez A, Urbanke H, Gillman AL, Lee J, Ryazanov S, Agbemenyah HY, Benito E, Jain G, Kaurani L, Grigorian G, Leonov A, Rezaei-Ghaleh N, Wilken P, Arce FT, Wagner J, Fuhrmann M, Caruana M, Camilleri A, Vassallo N, Zweckstetter M, Benz R, Giese A, Schneider A, Korte M, Lal R, Griesinger C, Eichele G, Fischer A. Martinez Hernandez A, et al. Among authors: ryazanov s. EMBO Mol Med. 2018 Jan;10(1):32-47. doi: 10.15252/emmm.201707825. EMBO Mol Med. 2018. PMID: 29208638 Free PMC article.
Photophysics of diphenyl-pyrazole compounds in solutions and α-synuclein aggregates.
Reiner AM, Schmidt F, Ryazanov S, Leonov A, Weckbecker D, Deeg AA, Griesinger C, Giese A, Zinth W. Reiner AM, et al. Among authors: ryazanov s. Biochim Biophys Acta Gen Subj. 2018 Apr;1862(4):800-807. doi: 10.1016/j.bbagen.2017.12.007. Epub 2017 Dec 19. Biochim Biophys Acta Gen Subj. 2018. PMID: 29273222
34 results