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The recent emergence of a highly related virulent Clostridium difficile clade with unique characteristics.
Shaw HA, Preston MD, Vendrik KEW, Cairns MD, Browne HP, Stabler RA, Crobach MJT, Corver J, Pituch H, Ingebretsen A, Pirmohamed M, Faulds-Pain A, Valiente E, Lawley TD, Fairweather NF, Kuijper EJ, Wren BW. Shaw HA, et al. Among authors: stabler ra. Clin Microbiol Infect. 2020 Apr;26(4):492-498. doi: 10.1016/j.cmi.2019.09.004. Epub 2019 Sep 13. Clin Microbiol Infect. 2020. PMID: 31525517 Free PMC article.
The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome.
Sebaihia M, Wren BW, Mullany P, Fairweather NF, Minton N, Stabler R, Thomson NR, Roberts AP, Cerdeño-Tárraga AM, Wang H, Holden MT, Wright A, Churcher C, Quail MA, Baker S, Bason N, Brooks K, Chillingworth T, Cronin A, Davis P, Dowd L, Fraser A, Feltwell T, Hance Z, Holroyd S, Jagels K, Moule S, Mungall K, Price C, Rabbinowitsch E, Sharp S, Simmonds M, Stevens K, Unwin L, Whithead S, Dupuy B, Dougan G, Barrell B, Parkhill J. Sebaihia M, et al. Nat Genet. 2006 Jul;38(7):779-86. doi: 10.1038/ng1830. Epub 2006 Jun 25. Nat Genet. 2006. PMID: 16804543
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