Gomes AS - Search Results

1

SLMP53-1 interacts with wild-type and mutant p53 DNA-binding domain and reactivates multiple hotspot mutations.

Gomes AS, Ramos H, Gomes S, Loureiro JB, Soares J, Barcherini V, Monti P, Fronza G, Oliveira C, Domingues L, Bastos M, Dourado DFAR, Carvalho AL, Romão MJ, Pinheiro B, Marcelo F, Carvalho A, Santos MMM, Saraiva L. Gomes AS, et al. Among authors: gomes s. Biochim Biophys Acta Gen Subj. 2020 Jan;1864(1):129440. doi: 10.1016/j.bbagen.2019.129440. Epub 2019 Sep 16. Biochim Biophys Acta Gen Subj. 2020. PMID: 31536751

2

The Crystal Structure of the R280K Mutant of Human p53 Explains the Loss of DNA Binding.

Gomes AS, Trovão F, Andrade Pinheiro B, Freire F, Gomes S, Oliveira C, Domingues L, Romão MJ, Saraiva L, Carvalho AL. Gomes AS, et al. Among authors: gomes s. Int J Mol Sci. 2018 Apr 13;19(4):1184. doi: 10.3390/ijms19041184. Int J Mol Sci. 2018. PMID: 29652801 Free PMC article.

3

DIMP53-1: a novel small-molecule dual inhibitor of p53-MDM2/X interactions with multifunctional p53-dependent anticancer properties.

Soares J, Espadinha M, Raimundo L, Ramos H, Gomes AS, Gomes S, Loureiro JB, Inga A, Reis F, Gomes C, Santos MMM, Saraiva L. Soares J, et al. Among authors: gomes s, gomes c, gomes as. Mol Oncol. 2017 Jun;11(6):612-627. doi: 10.1002/1878-0261.12051. Epub 2017 May 2. Mol Oncol. 2017. PMID: 28296148 Free PMC article.

4

p53 and glucose metabolism: an orchestra to be directed in cancer therapy.

Gomes AS, Ramos H, Soares J, Saraiva L. Gomes AS, et al. Pharmacol Res. 2018 May;131:75-86. doi: 10.1016/j.phrs.2018.03.015. Epub 2018 Mar 23. Pharmacol Res. 2018. PMID: 29580896 Review.

5

Structural and Drug Targeting Insights on Mutant p53.

Gomes AS, Ramos H, Inga A, Sousa E, Saraiva L. Gomes AS, et al. Cancers (Basel). 2021 Jul 3;13(13):3344. doi: 10.3390/cancers13133344. Cancers (Basel). 2021. PMID: 34283062 Free PMC article. Review.

6

Synthesis, Biological Evaluation, and In Silico Studies of Novel Aminated Xanthones as Potential p53-Activating Agents.

Lemos A, Gomes AS, Loureiro JB, Brandão P, Palmeira A, Pinto MMM, Saraiva L, Sousa ME. Lemos A, et al. Among authors: gomes as. Molecules. 2019 May 22;24(10):1975. doi: 10.3390/molecules24101975. Molecules. 2019. PMID: 31121972 Free PMC article.

7

Folic acid-mesoporous silicon nanoparticles enhance the anticancer activity of the p73-activating small molecule LEM2.

Gomes AS, Correia A, Rahikkala A, Mäkilä E, Pinto MM, Sousa E, Salonen J, Saraiva L, Santos HA. Gomes AS, et al. Int J Pharm. 2022 Aug 25;624:121959. doi: 10.1016/j.ijpharm.2022.121959. Epub 2022 Jul 2. Int J Pharm. 2022. PMID: 35792422 Free article.

8

Naphthoquinoxaline metabolite of mitoxantrone is less cardiotoxic than the parent compound and it can be a more cardiosafe drug in anticancer therapy.

Reis-Mendes A, Gomes AS, Carvalho RA, Carvalho F, Remião F, Pinto M, Bastos ML, Sousa E, Costa VM. Reis-Mendes A, et al. Among authors: gomes as. Arch Toxicol. 2017 Apr;91(4):1871-1890. doi: 10.1007/s00204-016-1839-z. Epub 2016 Sep 14. Arch Toxicol. 2017. PMID: 27629428

9

The Antitumor Activity of a Lead Thioxanthone is Associated with Alterations in Cholesterol Localization.

Lima RT, Sousa D, Gomes AS, Mendes N, Matthiesen R, Pedro M, Marques F, Pinto MM, Sousa E, Vasconcelos MH. Lima RT, et al. Among authors: gomes as. Molecules. 2018 Dec 12;23(12):3301. doi: 10.3390/molecules23123301. Molecules. 2018. PMID: 30545153 Free PMC article.

10

Screening a Small Library of Xanthones for Antitumor Activity and Identification of a Hit Compound which Induces Apoptosis.

Barbosa J, Lima RT, Sousa D, Gomes AS, Palmeira A, Seca H, Choosang K, Pakkong P, Bousbaa H, Pinto MM, Sousa E, Vasconcelos MH, Pedro M. Barbosa J, et al. Among authors: gomes as. Molecules. 2016 Jan 13;21(1):81. doi: 10.3390/molecules21010081. Molecules. 2016. PMID: 26771595 Free PMC article.

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