Hirasawa K - Search Results

1

Systemic MEK inhibition enhances the efficacy of 5-aminolevulinic acid-photodynamic therapy.

Chelakkot VS, Som J, Yoshioka E, Rice CP, Rutihinda SG, Hirasawa K. Chelakkot VS, et al. Among authors: hirasawa k. Br J Cancer. 2019 Oct;121(9):758-767. doi: 10.1038/s41416-019-0586-3. Epub 2019 Sep 25. Br J Cancer. 2019. PMID: 31551581 Free PMC article.

2

Enhancement of Cancer-Specific Protoporphyrin IX Fluorescence by Targeting Oncogenic Ras/MEK Pathway.

Yoshioka E, Chelakkot VS, Licursi M, Rutihinda SG, Som J, Derwish L, King JJ, Pongnopparat T, Mearow K, Larijani M, Dorward AM, Hirasawa K. Yoshioka E, et al. Among authors: hirasawa k. Theranostics. 2018 Mar 8;8(8):2134-2146. doi: 10.7150/thno.22641. eCollection 2018. Theranostics. 2018. PMID: 29721068 Free PMC article.

3

MEK reduces cancer-specific PpIX accumulation through the RSK-ABCB1 and HIF-1α-FECH axes.

Chelakkot VS, Liu K, Yoshioka E, Saha S, Xu D, Licursi M, Dorward A, Hirasawa K. Chelakkot VS, et al. Among authors: hirasawa k. Sci Rep. 2020 Dec 17;10(1):22124. doi: 10.1038/s41598-020-79144-x. Sci Rep. 2020. PMID: 33335181 Free PMC article.

4

A Novel Small Molecule Inhibits Hepatitis C Virus Propagation in Cell Culture.

Oraby AK, Gardner CL, Needle RF, Kofahi HM, Everard KR, Taylor NGA, Rutihinda SG, Barry JP, Hirasawa K, Georghiou PE, Russell RS. Oraby AK, et al. Among authors: hirasawa k. Microbiol Spectr. 2021 Sep 3;9(1):e0043921. doi: 10.1128/Spectrum.00439-21. Epub 2021 Jul 28. Microbiol Spectr. 2021. PMID: 34319169 Free PMC article.

5

Restoration of IRF1-dependent anticancer effects by MEK inhibition in human cancer cells.

AbuSara N, Razavi S, Derwish L, Komatsu Y, Licursi M, Hirasawa K. AbuSara N, et al. Among authors: hirasawa k. Cancer Lett. 2015 Feb 28;357(2):575-81. doi: 10.1016/j.canlet.2014.12.017. Epub 2014 Dec 10. Cancer Lett. 2015. PMID: 25497010

6

Suppression of IFN-induced transcription underlies IFN defects generated by activated Ras/MEK in human cancer cells.

Christian SL, Zu D, Licursi M, Komatsu Y, Pongnopparat T, Codner DA, Hirasawa K. Christian SL, et al. Among authors: hirasawa k. PLoS One. 2012;7(9):e44267. doi: 10.1371/journal.pone.0044267. Epub 2012 Sep 7. PLoS One. 2012. PMID: 22970192 Free PMC article.

7

IRF1 Downregulation by Ras/MEK Is Independent of Translational Control of IRF1 mRNA.

Komatsu Y, Derwish L, Hirasawa K. Komatsu Y, et al. Among authors: hirasawa k. PLoS One. 2016 Aug 10;11(8):e0160529. doi: 10.1371/journal.pone.0160529. eCollection 2016. PLoS One. 2016. PMID: 27508303 Free PMC article.

8

Oncogenic Ras inhibits IRF1 to promote viral oncolysis.

Komatsu Y, Christian SL, Ho N, Pongnopparat T, Licursi M, Hirasawa K. Komatsu Y, et al. Among authors: hirasawa k. Oncogene. 2015 Jul 23;34(30):3985-93. doi: 10.1038/onc.2014.331. Epub 2014 Oct 27. Oncogene. 2015. PMID: 25347735

9

Negative regulation of the alpha interferon-induced antiviral response by the Ras/Raf/MEK pathway.

Battcock SM, Collier TW, Zu D, Hirasawa K. Battcock SM, et al. Among authors: hirasawa k. J Virol. 2006 May;80(9):4422-30. doi: 10.1128/JVI.80.9.4422-4430.2006. J Virol. 2006. PMID: 16611902 Free PMC article.

10

Activated Ras/MEK inhibits the antiviral response of alpha interferon by reducing STAT2 levels.

Christian SL, Collier TW, Zu D, Licursi M, Hough CM, Hirasawa K. Christian SL, et al. Among authors: hirasawa k. J Virol. 2009 Jul;83(13):6717-26. doi: 10.1128/JVI.02213-08. Epub 2009 Apr 22. J Virol. 2009. PMID: 19386709 Free PMC article.

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